Evidence map›Paper›PMID 37995041›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2024

Synthesis and antifungal evaluation against Candida spp. of the (E)-3-(furan-2-yl)acrylic acid.

Paulo César Trindade da Costa, Thales Luciano Bezerra Santos, Jaqueline Ferreira Ramos, Jonh Anderson Macêdo Santos, Francinalva Dantas de Medeiros, Juliano Carlo Rufino Freitas, Wylly Araújo de Oliveira

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Paulo César Trindade da CostaHealth Sciences Center, Federal University of Paraiba, Cidade Universitária, João Pessoa, PB, 58051-900, Brazil. paulocesarnutricionista@gmail.com.ORCID http://orcid.org/0000-0003-3273-2399
Thales Luciano Bezerra SantosEducation and Health Center, Professora Maria Anita Furtado Coelho, Bairro Sítio Olho D'água da Bica, Federal University of Campina Grande, Cuité, PB, 58175-000, Brazil.ORCID http://orcid.org/0000-0002-8341-9012
Jaqueline Ferreira RamosDepartment of Chemistry, Federal Rural University of Pernambuco, Dom Manoel de Medeiros, Recife, PE, 52171-900, Brazil.ORCID http://orcid.org/0000-0001-7836-9359
Jonh Anderson Macêdo SantosDepartment of Chemistry, Federal Rural University of Pernambuco, Dom Manoel de Medeiros, Recife, PE, 52171-900, Brazil.ORCID http://orcid.org/0000-0002-6591-5194
Francinalva Dantas de MedeirosEducation and Health Center, Professora Maria Anita Furtado Coelho, Bairro Sítio Olho D'água da Bica, Federal University of Campina Grande, Cuité, PB, 58175-000, Brazil.ORCID http://orcid.org/0000-0003-1812-6966
Juliano Carlo Rufino FreitasEducation and Health Center, Professora Maria Anita Furtado Coelho, Bairro Sítio Olho D'água da Bica, Federal University of Campina Grande, Cuité, PB, 58175-000, Brazil.ORCID http://orcid.org/0000-0003-4617-4084
Wylly Araújo de OliveiraEducation and Health Center, Professora Maria Anita Furtado Coelho, Bairro Sítio Olho D'água da Bica, Federal University of Campina Grande, Cuité, PB, 58175-000, Brazil.ORCID http://orcid.org/0000-0002-7784-0302
Universidade Federal de Campina Grande · BRUniversidade Federal Rural de Pernambuco · BRUniversidade Federal da Paraíba · BR

Funding

Fundação de Apoio à Pesquisa do Estado da Paraíba 3157/2021National Council for Scientific and Technological Development 434012/2018-1
6 · The paper itself

Abstract

Infections of fungal origin are mainly caused by Candida spp. Some species, such as C. albicans, C. glabrata, C. parapsilosis, and C. tropicalis, stand out as promoters of diseases in humans. This study evaluated the synthesis and antifungal effects of (E)-3-(furan-2-yl)acrylic acid. The synthesis of the compound showed a yield of 88%, considered high. The minimum inhibitory concentration of the synthetic compound, amphotericin B, and fluconazole isolated against four Candida species ranged from 64 to 512 μg/mL, 1 to 2 μg/mL, and 32 to 256 μg/mL, respectively. The synergistic effect of the test compound was observed when associated with amphotericin B against C. albicans and C. tropicalis, with no antagonism between the substances against any of the strains tested. The potential drug promoted morphological changes in C. albicans, decreasing the amount of resistance and virulence, and reproduction structures, such as the formation of pseudohyphae, blastoconidia, and chlamydospores. Furthermore, it was also possible to identify the fungistatic profile of the test substance by studying the growth kinetics of C. albicans. Finally, it was observed that the test compound stimulated ergosterol biosynthesis by the yeast, probably by activating microbial resistance responses.

Indexed as

Antifungal AgentsCandidaAcrylatesAmphotericin BCandida albicansCandida glabrataCandida parapsilosisDrug Resistance, FungalFluconazoleHumansMicrobial Sensitivity TestsAcrylatesacrylic acidAmphotericin BAntifungal AgentsFluconazoleAntimicrobialCandidaCheckerboardErgosterolMorphological transition

Identifiers

PMID37995041
PMCPMC10920609
OpenAlexW4388928543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.