Evidence map›Paper›PMID 37994829›Full record

ArticleBrain and language2023

A comparison of functional activation and connectivity of the cerebellum in adults and children during single word processing.

Sikoya M Ashburn, D Lynn Flowers, Guinevere F Eden

Open access · greenAbstract read
In one paragraph

Article in Brain and language, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sikoya M AshburnCenter for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, DC, United States.
D Lynn FlowersCenter for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, DC, United States.
Guinevere F EdenCenter for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, DC, United States. Electronic address: edeng@georgetown.edu.
Georgetown University · US

Funding

NEUROIMAGING COREP30HD040677 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI MCCARTER, ROBERT JAMES · 2001 to 2015
$15.9M
Reading and sensorimotor fluency in dyslexiaP50HD040095 · NICHD · GEORGETOWN UNIVERSITY · PI EDEN, GUINEVERE F. · 2001 to 2006
$7.5M
Translational Biomedical Science Training GrantTL1TR001431 · NCATS · GEORGETOWN UNIVERSITY · PI LEE, DEXTER L, SANDBERG, KATHRYN L · 2015 to 2024
$4.8M
Training in Neural Injury &PlasticityT32NS041218 · NINDS · GEORGETOWN UNIVERSITY · PI MARK P BURNS, Kathleen Anne Maguire-Zeiss · 2001 to 2026
$3.5M
Supplement for Sikoya Ashburn to "An fMRI Study on the Neural Basis of Combined Math and Reading Disability"R01HD081078 · NICHD · GEORGETOWN UNIVERSITY · PI EDEN, GUINEVERE F. · 2015 to 2019
$3.0M
NCATS NIH HHS TL1 TR001431NICHD NIH HHS P30 HD040677NICHD NIH HHS P50 HD040095NICHD NIH HHS R01 HD081078NINDS NIH HHS T32 NS041218
6 · The paper itself

Abstract

Meta-analyses on reading show cerebellar activation in adults, but not children, suggesting a possible age-dependent role of the cerebellum in reading. However, the few studies that compare adults and children during reading report mixed cerebellar activation results. Here, we studied (i) cerebellar activation during implicit word processing in adults and children and (ii) functional connectivity (FC) between the cerebellum and left cortical regions involved in reading. First, both groups activated bilateral cerebellum for word processing when compared to fixation, but not when compared to the active control. There were no differences between adults and children. Second, we found intrinsic FC between several cerebellar seed regions and cortical target regions in adults and children, as well as between-group differences. However, task-modulated FC specific to word processing revealed no within- nor between-group results. Together this study does not provide support for a role of the cerebellum in word processing at either age.

Indexed as

Brain MappingWord ProcessingAdultCerebellumCerebral CortexChildHumansMagnetic Resonance ImagingReadingAdultsCerebellumChildrenFunctional ActivationFunctional ConnectivityReading

Identifiers

PMID37994829
PMCPMC10722870
OpenAlexW4388182924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.