Evidence map›Paper›PMID 37994442›Full record

SynthesisPathogens and global health2024

A systematic review of CQ-resistant

Vishnu Teja Nallapati, Nitin Gupta, Manjunath H Hande, Kavitha Saravu

Abstract readSystematic Review
In one paragraph

Synthesis in Pathogens and global health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vishnu Teja NallapatiDepartment of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education, Karnataka, Manipal, India.
Nitin GuptaDepartment of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education, Karnataka, Manipal, India.
Manjunath H HandeDepartment of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Karnataka, Manipal, India.
Kavitha SaravuDepartment of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education, Karnataka, Manipal, India.ORCID 0000-0001-6399-1129

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChloroquine (CQ) is the drug of choice for treating uncomplicated

methodsPubMed, EMBASE, and Web of Science, were searched using the search string: 'Malaria AND vivax AND chloroquine AND (resistance OR resistant) AND India'. We systematically reviewed in-vivo and in-vitro drug efficacy studies that investigated the CQ efficacy of

resultsWe identified 12 eligible CQ therapeutic efficacy studies involving 2470 patients, Of these 2329 patients were assessed by in-vivo therapeutic efficacy methods and the remaining 141 were assessed by in-vitro methods. CQ resistance was found in 25/1787 (1.39%) patients from in-vivo and in 11/141 (7.8%) patients from in-vitro drug efficacy studies.

conclusionBased on the available studies, the prevalence of CQ resistance in

Indexed as

AntimalarialsChloroquineDrug ResistanceMalaria, VivaxPlasmodium vivaxHumansIndiaPrevalenceAntimalarialsChloroquineChloroquine resistancein-vitro CQ efficacyin-vivo efficacyp. vivaxtreatment failures

Identifiers

PMID37994442
PMCPMC11234910

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.