Evidence map›Paper›PMID 37994421›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates.

Simone Giovannuzzi, Anil Kumar Marapaka, Nader S Abutaleb, Fabrizio Carta, Hsin-Wen Liang, Alessio Nocentini, Luigi Pisano, Mohamed N Seleem, Daniel P Flaherty, Claudiu T Supuran

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Simone GiovannuzziNeurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino (FI), Italy.
Anil Kumar MarapakaDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, IN, USA.
Nader S AbutalebDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Fabrizio CartaNeurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino (FI), Italy.
Hsin-Wen LiangDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Alessio NocentiniNeurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino (FI), Italy.
Luigi PisanoSection of Dermatology, Health Sciences Department, University of Florence, Florence, Italy.
Mohamed N SeleemDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Daniel P FlahertyDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, IN, USA.ORCID 0000-0002-8305-0606
Claudiu T SupuranNeurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino (FI), Italy.ORCID 0000-0003-4262-0323
University of Florence · ITVirginia–Maryland College of Veterinary Medicine · USPurdue Pharma (Canada) · CAPurdue University West Lafayette · US

Funding

Repurposing novel selective drugs for treatment and decolonization of vancomycin resistant enterococciR01AI148523 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Daniel Patrick Flaherty, Mohamed Seleem · 2019 to 2026
$4.2M
Development of novel anti-Neisseria gonorrhoeae therapeutic agentsR01AI153264 · NIAID · PURDUE UNIVERSITY · PI FLAHERTY, DANIEL PATRICK · 2022 to 2025
$3.1M
NIAID NIH HHS R01 AI148523NIAID NIH HHS R01 AI153264
6 · The paper itself

Abstract

Carbonic anhydrases (CAs) from the pathogenic bacteria

Indexed as

Carbonic AnhydrasesVancomycin-Resistant EnterococciAnti-Bacterial AgentsBacteriaCarbonic Anhydrase InhibitorsAnti-Bacterial AgentsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesAntibacterialscarbonic anhydrase inhibitormonothiocarbamatesNeisseria gonorrhoeaevancomycin-resistant enterococci

Identifiers

PMID37994421
PMCPMC11003479
OpenAlexW4388928854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.