Evidence map›Paper›PMID 37994408›Full record

ArticleAutoimmunity2023

Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus.

Mei-Ling Yang, TuKiet T Lam, Jean Kanyo, Insoo Kang, Zhaohui Sunny Zhou, Steven G Clarke, Mark J Mamula

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autoimmunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mei-Ling YangSection of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Yale University, New Haven, CT, USA.
TuKiet T LamKeck MS & Proteomics Resource, WM Keck Foundation Biotechnology Resource Laboratory, New Haven, CT, USA.
Jean KanyoKeck MS & Proteomics Resource, WM Keck Foundation Biotechnology Resource Laboratory, New Haven, CT, USA.
Insoo KangSection of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Yale University, New Haven, CT, USA.
Zhaohui Sunny ZhouDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
Steven G ClarkeDepartment of Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Mark J MamulaSection of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Yale University, New Haven, CT, USA.
Yale University · USNortheastern University · USW. M. Keck Foundation · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Post Translational Modifications in Tolerance and AutoimmunityR01AI048120 · NIAID · YALE UNIVERSITY · PI MAMULA, MARK J · 2001 to 2019
$5.6M
MOLECULAR MECHANISMS OF LYMPHOCYTE INTERACTIONS IN SLER01AR041032 · NIAMS · YALE UNIVERSITY · PI MAMULA, MARK J · 1997 to 2011
$2.4M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI048120NIAMS NIH HHS R01 AR041032
6 · The paper itself

Abstract

Protein posttranslational modifications (PTMs) arise in a number of normal cellular biological pathways and in response to pathology caused by inflammation and/or infection. Indeed, a number of PTMs have been identified and linked to specific autoimmune responses and metabolic pathways. One particular PTM, termed isoaspartyl (isoAsp or isoD) modification, is among the most common spontaneous PTM occurring at physiological pH and temperature. Herein, we demonstrate that isoAsp modifications arise within the ZAP70 protein tyrosine kinase upon T-cell antigen receptor (TCR) engagement. The enzyme protein

Indexed as

Protein D-Aspartate-L-Isoaspartate MethyltransferaseT-LymphocytesAutoimmunityHumansOxidative StressProtein Processing, Post-TranslationalZAP-70 Protein-Tyrosine KinaseProtein D-Aspartate-L-Isoaspartate MethyltransferaseZAP70 protein, humanZAP-70 Protein-Tyrosine Kinaseisoaspartyl modificationposttranslational modificationsprotein L-isoaspartate O-methyltransferasesystemic lupus erythematosusTCR signaling

Identifiers

PMID37994408
PMCPMC10897934
OpenAlexW4388932226

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.