Evidence map›Paper›PMID 37994265›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2024

Mitigation of Osteoclast-Mediated Arthritic Bone Remodeling By Short Chain Fatty Acids.

Katharine Lu Yang, Briana J Mullins, Alannah Lejeune, Ellie Ivanova, Jong Shin, Sofia Bajwa, Richard Possemato, Ken Cadwell, Jose U Scher, Sergei B Koralov

Open access · bronzeAbstract read
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Intestinal-Bone Axis Mediated byMicroorganisms · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Katharine Lu YangNew York University Langone Health, New York City.
Briana J MullinsNew York University Langone Health, New York City.
Alannah LejeuneNew York University School of Medicine, New York City.
Ellie IvanovaNew York University Langone Health, New York City.
Jong ShinNew York University Langone Health, New York City.
Sofia BajwaNew York University Langone Health, New York City.
Richard PossematoNew York University Langone Health, New York City.
Ken CadwellNew York University Langone Health, New York City, and University of Pennsylvania Perelman School of Medicine, Philadelphia.
Jose U ScherNew York University Langone Health and New York University School of Medicine, New York City.ORCID 0000-0002-1072-6994
Sergei B KoralovNew York University Langone Health, New York City.ORCID 0000-0002-4843-3791
NYU Langone Health · USCity University of New York · US

Funding

TRAINING PROGRAM IN MOLECULAR ONCOLOGY &IMMUNOLOGYT32CA009161 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARROLL, WILLIAM L., LEVY, DAVID E · 1985 to 2020
$13.3M
Diabetes, Digestive, and Kidney Diseases Extramural ResearchR01DK093668 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2011 to 2026
$7.3M
Training Program in Immunology and Inflammation.T32AI100853 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Susan Ruth Schwab · 2012 to 2026
$4.5M
Employing the gut microbiome to accelerate effective initiation of rheumatoid arthritis therapyR01AR074500 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Renuka Rajendra Nayak, Jose U. Scher · 2019 to 2026
$4.1M
Mechanisms of MRSA intestinal colonizationR01AI140754 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO · 2020 to 2024
$3.5M
Interactions between helminth colonization and the gut microbiotaR01AI130945 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA · 2018 to 2022
$3.3M
Role of S.aureus in Cutaneous T Cell Lymphoma PathogenesisR01CA271245 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Sergei Borisovich Koralov · 2022 to 2026
$2.7M
National Psoriasis FoundationNCI NIH HHS R01 CA271245NCI NIH HHS T32 CA009161NIAID NIH HHS AI140754NIAID NIH HHS R01 AI130945NIAID NIH HHS R01 AI140754NIAID NIH HHS T32 AI100853NIAMS NIH HHS R01 AR074500NIDDK NIH HHS DK-093668NIDDK NIH HHS R01 DK093668NIH HHS R01 AR074500NIH HHS R01-CA-271245
6 · The paper itself

Abstract

objectiveThe objective for this study was to evaluate the effects of short chain fatty acids (SCFAs) on arthritic bone remodeling.

methodsWe treated a recently described preclinical murine model of psoriatic arthritis (PsA), R26STAT3C

resultsThe osteoporosis condition in R26STAT3C

conclusionWe demonstrated how gut microbiota-derived SCFAs can regulate distal pathology (ie, osteoporosis) and identified a potential therapeutic option for restoring bone density in rheumatic disease, further highlighting the critical role of the gut-bone axis in these disorders.

Indexed as

Arthritis, PsoriaticOsteoporosisAnimalsBone RemodelingCell DifferentiationFatty Acids, VolatileMiceOsteoclastsFatty Acids, Volatile

Identifiers

PMID37994265
PMCPMC10965381
OpenAlexW4388946768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.