Evidence map›Paper›PMID 37994088›Full record

ReviewJournal of chest surgery2024

Prothrombin Complex Concentrate versus Fresh Frozen Plasma in Adult Patients Undergoing Cardiac Surgery: A Systematic Review and Meta-Analysis.

Patricia Viana, Jessica Hoffmann Relvas, Marina Persson, Thamiris Dias Delfino Cabral, Jorge Eduardo Persson, Jessica Sales de Oliveira, Paulo Bonow, Camila Veronica Souza Freire, Sara Amaral

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of chest surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Blood transfusion and acute kidney injury after cardiac surgery: a retrospective observational study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
    Observational
  7. Review
  8. [Treatment with blood products in the intensive care unit].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Patricia VianaDepartment of Medicine, Universidade do Extremo Sul Catarinense, Criciuma, Brazil.ORCID https://orcid.org/0000-0002-8139-3963
Jessica Hoffmann RelvasDepartment of Internal Medicine, Conjunto Hospitalar do Mandaqui, São Paulo, Brazil.ORCID https://orcid.org/0009-0005-3689-5779
Marina PerssonDepartment of Medicine, Universidade Federal de Pelotas, Pelotas, Brazil.ORCID https://orcid.org/0000-0002-9719-5304
Thamiris Dias Delfino CabralDepartment of Medicine, Faculdade de Medicina Souza Marques, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-7143-5085
Jorge Eduardo PerssonDepartment of Medicine, Universidade do Extremo Sul Catarinense, Criciuma, Brazil.ORCID https://orcid.org/0009-0000-4790-8700
Jessica Sales de OliveiraDepartment of Medicine, National University of Rosario-UNR, Rosario, Argentina.ORCID https://orcid.org/0000-0002-2783-0122
Paulo BonowDepartment of Medicine, Universidade Federal de Pelotas, Pelotas, Brazil.ORCID https://orcid.org/0009-0009-3079-3375
Camila Veronica Souza FreireDepartment of Medicine, Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.ORCID https://orcid.org/0000-0003-1873-3512
Sara AmaralDepartment of Anesthesiology, Universidade Nova de Lisboa, Lisbon, Portugal.ORCID https://orcid.org/0000-0001-5399-668X
Universidade do Extremo Sul Catarinense · BRUniversidade Federal de Pelotas · BREscola Bahiana de Medicina e Saúde Pública · BRFundação Técnico Educacional Souza Marques · BRNational University of Rosario · ARUniversidade Nova de Lisboa · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prothrombin complex concentrate (PCC) and fresh frozen plasma (FFP) are commonly used to manage bleeding in patients during cardiac surgery. However, the relative efficacy and safety of these 2 strategies remain uncertain. Methods: MEDLINE, Embase, and Cochrane were searched for studies comparing PCC and FFP in patients who underwent cardiac surgery complicated by bleeding. Review Manager (RevMan) ver. 5.4 (Nordic Cochrane Centre, The Cochrane Collaboration) was used for statistical analysis. Binary and continuous outcomes were compared using pooled risk ratios and mean differences, respectively. The meta-analysis protocol was registered in the International Prospective Register of Systematic Reviews under protocol number CRD42022379144. Results: We included 8 studies with 1,500 patients, of whom 613 (40.9%) received PCC. The mean follow-up period ranged from 28 to 90 days. The PCC group had significantly lower chest tube drainage at 24 hours (mean difference [MD], -148.50 mL; 95% CI, -253.02 to -43.99 mL; p=0.005; I Conclusion: Our findings suggest that PCC can be effective, without increased adverse events, when compared with FFP in patients undergoing cardiac surgery complicated by bleeding.

Indexed as

HemorrhageMeta-analysisPlasmaProthrombin complex concentrateThoracic surgery

Identifiers

PMID37994088
PMCPMC10792384
OpenAlexW4388930572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.