Evidence map›Paper›PMID 37993980›Full record

ArticleThe British journal of psychiatry : the journal of mental science2024

Association of hippocampal subfield volumes with prevalence, course and incidence of depressive symptoms: The Maastricht Study.

Jennifer Monereo-Sánchez, Jacobus F A Jansen, Martin P J van Boxtel, Walter H Backes, Sebastian Köhler, Coen D A Stehouwer, David E J Linden, Miranda T Schram

Abstract read
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Hippocampal Total, Subregion, and Subfield Volume Alterations in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennifer Monereo-SánchezSchool for Mental Health & Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands; and Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, the Netherlands.
Jacobus F A JansenSchool for Mental Health & Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands; and Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, the Netherlands.
Martin P J van BoxtelAlzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands.
Walter H BackesSchool for Mental Health & Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands; Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, the Netherlands; and School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands.
Sebastian KöhlerSchool for Mental Health & Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands; and Department of Psychiatry and Neuropsychology, Maastricht University Medical Center, the Netherlands.
Coen D A StehouwerSchool for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands; Department of Psychiatry and Neuropsychology, Maastricht University Medical Center, the Netherlands; and Department of Internal Medicine, Maastricht University Medical Center, the Netherlands.
David E J LindenSchool for Mental Health & Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands.
Miranda T SchramSchool for Mental Health & Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands; School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands; Department of Internal Medicine, Maastricht University Medical Center, the Netherlands; and Maastricht Heart + Vascular Center, Maastricht University Medical Center, the Netherlands.ORCID 0000-0001-8113-7604

Funding

European Regional Development Fund 31O.041
6 · The paper itself

Abstract

backgroundLate-life depression has been associated with volume changes of the hippocampus. However, little is known about its association with specific hippocampal subfields over time.

aimsWe investigated whether hippocampal subfield volumes were associated with prevalence, course and incidence of depressive symptoms.

methodWe extracted 12 hippocampal subfield volumes per hemisphere with FreeSurfer v6.0 using

resultsA total of

conclusionsDifferences in hippocampal fissure, molecular layer and CA volumes might co-occur or follow the onset of depressive symptoms, in particular with a chronic course. Smaller HATA was associated with an increased risk of incident (chronic) depression. Our results could capture a biological foundation for the development of chronic depressive symptoms, and stresses the need to discriminate subtypes of depression to unravel its biological underpinnings.

Indexed as

DepressionHippocampusFemaleHumansIncidenceMagnetic Resonance ImagingMaleMiddle AgedOrgan SizePrevalenceTemporal Lobecognitive neurosciencedepressive disordersMagnetic resonance imagingneuroanatomyneuropathology

Identifiers

PMID37993980
PMCPMC10807974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.