Evidence map›Paper›PMID 37993966›Full record

ArticleGenome medicine2023

Massive underrepresentation of Arabs in genomic studies of common disease.

Romit Bhattacharya, NingNing Chen, Injeong Shim, Hiroyuki Kuwahara, Xin Gao, Fowzan S Alkuraya, Akl C Fahed

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Cancer Genetics in the Arab World.Technology in cancer research & treatment
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Romit Bhattacharya *Department of Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street | CPZN 3.128, Boston, MA, 02114, USA.
NingNing Chen *Computational Biosciences Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Injeong ShimDepartment of Medicine, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hiroyuki KuwaharaComputational Biosciences Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Xin Gao *Computational Biosciences Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Fowzan S Alkuraya *Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia. FAlKuraya@kfshrc.edu.sa.
Akl C Fahed *Department of Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street | CPZN 3.128, Boston, MA, 02114, USA. afahed@mgh.harvard.edu.ORCID 0000-0002-4849-6389

Funding

Integrating genomic and nongenomic risk for coronary artery diseaseK08HL161448 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Akl C Fahed · 2022 to 2026
$751k
NHLBI NIH HHS 1K08HL161448NHLBI NIH HHS K08 HL161448
6 · The paper itself

Abstract

Arabs represent 5% of the world population and have a high prevalence of common disease, yet remain greatly underrepresented in genome-wide association studies, where only 1 in 600 individuals are Arab. We highlight the persistent and unaddressed underrepresentation of Arabs in genomic databases and discuss its impact on public health genomics and missed opportunities for biological discovery.

Indexed as

ArabsGenome-Wide Association StudyGenomeGenomicsHumansArabDiversityGenomicGWASMiddle EastPolygenic scoreUnderrepresentation

Identifiers

PMID37993966
PMCPMC10664351

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.