Evidence map›Paper›PMID 37993950›Full record

ArticleVeterinary research2023

Characterization of translocon proteins in the type III secretion system of Lawsonia intracellularis.

Beibei Huang, Zihe Zhu, Yimin Dai, Chengxian Yan, Jingyu Xu, Lingling Sun, Qinghua Zhang, Xuejiao An, Fenju Lai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Beibei HuangSchool of Bioscience and Bioengineering, Nanchang Key Laboratory of Fermentation Application Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
Zihe ZhuSchool of Bioscience and Bioengineering, Nanchang Key Laboratory of Fermentation Application Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
Yimin DaiSchool of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
Chengxian YanSchool of Bioscience and Bioengineering, Nanchang Key Laboratory of Fermentation Application Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
Jingyu XuSchool of Bioscience and Bioengineering, Nanchang Key Laboratory of Fermentation Application Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
Lingling SunSchool of Bioscience and Bioengineering, Nanchang Key Laboratory of Fermentation Application Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
Qinghua ZhangSchool of Bioscience and Bioengineering, Nanchang Key Laboratory of Fermentation Application Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
Xuejiao AnSchool of Bioscience and Bioengineering, Nanchang Key Laboratory of Fermentation Application Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
Fenju LaiJiangxi Engineering Laboratory for the Development and Utilization of Agricultural Microbial Resources, Nanchang, Jiangxi, China. laifenju@jxau.edu.cn.ORCID http://orcid.org/0000-0002-9036-470X
Jiangxi Agricultural University · CN

Funding

National Natural Science Foundation of China 31660720National Natural Science Foundation of China 31802213
6 · The paper itself

Abstract

Lawsonia intracellularis, the etiologic agent of proliferative enteropathy (PE), is an obligate intracellular Gram-negative bacterium possessing a type III secretion system (T3SS), which enables the pathogen to translocate effector proteins into targeted host cells to modulate their functions. T3SS is a syringe-like apparatus consisting of a base, an extracellular needle, a tip, and a translocon. The translocon proteins assembled by two hydrophobic membrane proteins can form pores in the host-cell membrane, and therefore play an essential role in the function of T3SS. To date, little is known about the T3SS and translocon proteins of L. intracellularis. In this study, we first analyzed the conservation of the T3S apparatus between L. intracellularis and Yersinia, and characterized the putative T3S hydrophobic major translocon protein LI1158 and minor translocon protein LI1159 in the L. intracellularis genome. Then, by using Yersinia pseudotuberculosis as a surrogate system, we found that the full-length LI1158 and LI1159 proteins, but not the putative class II chaperone LI1157, were secreted in a - Ca

Indexed as

Lawsonia BacteriaAnimalsBacterial ProteinsEscherichia coliSaccharomyces cerevisiaeType III Secretion SystemsBacterial ProteinsType III Secretion SystemsLawsonia intracellularisProliferative enteropathytranslocon proteinstype III secretion system

Identifiers

PMID37993950
PMCPMC10664548
OpenAlexW4388903960

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.