Evidence map›Paper›PMID 37993909›Full record

ReviewCancer cell international2023

Circular RNAs in renal cell carcinoma: from mechanistic to clinical perspective.

Chunjie Huang, Pooya Esfani Sarafraz, Parisa Enayati, Elham Mortazavi Mamaghani, Emad Babakhanzadeh, Majid Nazari

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Cancer cell international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Circular RNAs and Cancers.Advances in experimental medicine and biology · 2025
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Chunjie HuangSchool of Medicine, Nantong University, Nantong, China.
Pooya Esfani SarafrazDepartment of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.
Parisa EnayatiBiological Sciences Department, Northern Illinois University, DeKalb, Illinois, USA.
Elham Mortazavi MamaghaniDepartment of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Emad BabakhanzadehDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Majid NazariDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, 64155-65117, Yazd, Iran. Vision.nazari@gmail.com.
Guilan University of Medical Sciences · IRIran University of Medical Sciences · IRNantong University · CNNorthern Illinois University · USShahid Beheshti University of Medical Sciences · IRShahid Sadoughi University of Medical Sciences and Health Services · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CircRNAs, a special type of noncoding RNAs characterized by their stable structure and unique abilities to form backsplicing loops, have recently attracted the interest of scientists. These RNAs are abundant throughout the body and play important roles such as microRNA sponges, templates for transcription, and regulation of protein translation and RNA-binding proteins. Renal cancer development is highly correlated with abnormal circRNA expression in vivo. CircRNAs are currently considered promising targets for novel therapeutic approaches as well as possible biomarkers for prognosis and diagnosis of various malignancies. Despite our growing understanding of circRNA, numerous questions remain unanswered. Here, we address the characteristics of circRNAs and their function, focusing in particular on their impact on drug resistance, metabolic processes, metastasis, cell growth, and programmed cell death in renal cancer. In addition, the application of circRNAs as prognostic and diagnostic biomarkers will be discussed.

Indexed as

BiomarkerCircRNARenal cell carcinomaTargeted therapy

Identifiers

PMID37993909
PMCPMC10664289
OpenAlexW4388912319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.