ArticleJournal of orthopaedic surgery and research2023
The impact of long-term aspirin use on the patients undergoing shoulder arthroplasty.
Article in Journal of orthopaedic surgery and research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Preoperative Hemoglobin Discriminates Perioperative Transfusion in Reverse Shoulder Arthroplasty: A Single-Center Preliminary Study with Internal Validation and a Candidate Blood-Preparation Threshold.Medicina (Kaunas, Lithuania) · 2026Article
- Pre-operative antiplatelet therapy is associated with increased risk of periprosthetic joint infection following total shoulder arthroplasty.Journal of shoulder and elbow arthroplasty · 2026Article
- Venous thromboembolism prophylaxis in total shoulder arthroplasty: a matched cohort analysis.Archives of orthopaedic and trauma surgery · 2026Article
- Effects of Dementia on Adverse Outcomes in Geriatric Patients Undergoing Elective Total Hip Arthroplasty: Analysis of the US Nationwide Inpatient Sample.Geriatric orthopaedic surgery & rehabilitation · 2026Article
- Navigating the challenges of catheter ablation in patients with comorbid alcohol use disorder.BMC cardiovascular disorders · 2025Article
- Osteoporosis exacerbates perioperative complications in total knee arthroplasty: a 10-Year nationwide analysis.Journal of orthopaedic surgery and research · 2025Article
- Article
- Long-term aspirin use and perioperative outcomes in lumbar interbody fusion: a population-based study using US national inpatient sample database.Journal of orthopaedic surgery and research · 2025Article
- Blood transfusion in percutaneous left atrial appendage occlusion: a nationwide analysis of incidence, predictors, and outcomes.BMC cardiovascular disorders · 2025Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough aspirin is increasingly utilized to reduce the event of severe perioperative complications, the effect of long-term aspirin use (L-AU) on perioperative complications in patients undergoing shoulder arthroplasty (SA) has not been well studied. The goal of the present study is to identify the influence of L-AU on perioperative complications in individuals undergoing SA.
methodsWe selected data from the National Inpatient Sample database between 2010 and 2019, to identify adult patients with SA. Patients were subsequently categorized into L-AU and whole non-L-AU cohorts according to the presence of aspirin use. The demographic and comorbidity characteristics were matched using propensity score matching (PSM). The Pearson chi-square test, Wilcoxon rank test and logistic regression were utilized to assess the association of L-AU with perioperative complications.
resultsFrom 2010 to 2019, a total of 162,418 SA patients satisfied the inclusion criteria, with 22,659 (13.95%) using aspirin on a long-term basis. The vast majority of the patients with pre-existing L-AU were aged 65-74 years, female, White and had Medicare insurance. L-AU before surgery was linked to increased risks of perioperative complications, such as blood transfusion (adjusted odds ratio [aOR]: 1.339), genitourinary disease (aOR: 1.349), acute renal failure (aOR: 1.292), acute myocardial infarction (aOR: 1.494), higher total charge (L-AU vs. the whole non-L-AU vs. matched non-L-AU: $66,727.15 vs. $59,697.08 vs. $59,926.32), and prolonged hospitalization stay (LOS) (aOR: 0.837). However, L-AU was considered a protective factor of acute cerebrovascular disease (aOR: 0.722) and stroke (aOR: 0.725).
conclusionsOur study is based on the largest open-access all-payer inpatient database, revealing a noteworthy finding of aspirin's protective and adverse impact on different postoperative complications in the US population, such as acute cardiovascular disease, and stroke, etc. Further studies assessing the optimum preoperative aspirin duration and dosage to meet the best benefit quantity for patients with planned joint arthroplasties are suggested.
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