Evidence map›Paper›PMID 37993797›Full record

ArticleBMC psychiatry2023

Association of bone turnover markers and cognitive function in Chinese chronic schizophrenia patients with or without vitamin D insufficiency.

Chen Ling, Liling Sun, Bei Luo, Haiyun Yu, Wei Li, Yating Yang, Huanzhong Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chen Ling *Department of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230032, China.
Liling Sun *Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, 238000, China.
Bei LuoDepartment of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230032, China.
Haiyun YuDepartment of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, 238000, China.
Wei LiDepartment of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, 238000, China.
Yating YangDepartment of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230032, China.
Huanzhong LiuDepartment of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230032, China. huanzhongliu@ahmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreasing evidence shows that bone turnover markers (BTMs) and vitamin D can affect human cognitive function. However, there are few studies that have investigated the association between BTMs and cognitive function in chronic schizophrenia patients. The aim of this study was to investigate the relationship between BTMs and cognitive function in chronic schizophrenia patients with or without vitamin D insufficiency (VDI).

methodsIn all, 118 chronic schizophrenia patients were enrolled in this cross-sectional study. Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was applied to evaluate the cognitive function of the subjects. Blood analysis included bone turnover markers, vitamin D levels, and glycolipid levels.

resultsRelative to 72 vitamin D-sufficient (VDS) patients, 46 VDI patients had higher bone resorption markers levels and lower bone formation markers levels. Regression analysis showed that, in the total sample, CTX and language function exhibited independent positive correlation (p = 0.027, R

conclusionOur study showed an association between the levels of BTMs and cognitive function among chronic schizophrenia patients. This correlation may have different mechanisms of action at different vitamin D levels.

Indexed as

SchizophreniaVitamin D DeficiencyBiomarkersBone RemodelingCognitionCollagen Type ICross-Sectional StudiesEast Asian PeopleHumansVitamin DVitaminsBiomarkersCollagen Type IProcollagen Type IVitamin DVitaminsBone turnover markersCognitive functionSchizophreniaVitamin D

Identifiers

PMID37993797
PMCPMC10664381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.