Evidence map›Paper›PMID 37993759›Full record

ReviewStem cell reviews and reports2024

Tracking of Stem Cells in Chronic Liver Diseases: Current Trends and Developments.

Jin-Long He, Yi-Xian You, Xiong Pei, Wei Jiang, Qing-Min Zeng, Bin Chen, Yong-Hong Wang, En-Qiang Chen, Hong Tang, Xiu-Feng Gao and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jin-Long He *West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610065, China.ORCID 0000-0003-0140-0922
Yi-Xian You *Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xiong PeiCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wei JiangCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Qing-Min ZengCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Bin ChenCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yong-Hong WangCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
En-Qiang ChenCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.ORCID 0000-0002-8523-1689
Hong TangCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.ORCID 0000-0002-9790-6225
Xiu-Feng GaoWest China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610065, China. xiufengg@163.com.ORCID 0000-0002-2846-0741
Dong-Bo WuCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China. dongbohuaxi@163.com.ORCID 0000-0003-4500-047X
Sichuan University · CNWest China Medical Center of Sichuan University · CN

Funding

National Key Research and Development Program of China 2022YFC2303700National Key Research and Development Program of China 2022YFC2304800National Natural Science Foundation of China 82172254
6 · The paper itself

Abstract

Stem cell therapy holds great promise for future clinical practice for treatment of advanced liver diseases. However, the fate of stem cells after transplantation, including the distribution, viability, and the cell clearance, has not been fully elucidated. Herein, recent advances regarding the imaging tools for stem cells tracking mainly in chronic liver diseases with the advantages and disadvantages of each approach have been described. Magnetic resonance imaging is a promising clinical imaging modality due to non-radioactivity, excellent penetrability, and high spatial resolution. Fluorescence imaging and radionuclide imaging demonstrate relatively increased sensitivity, with the latter excelling in real-time monitoring. Reporter genes specialize in long-term tracing. Nevertheless, the disadvantages of low sensitivity, radiation, exogenous gene risk are inevitably present in each of these means, respectively. In this review, we aim to comprehensively evaluate the current state of methods for tracking of stem cell, highlighting their strengths and weaknesses, and providing insights into their future potential. Multimodality imaging strategies may overcome the inherent limitations of single-modality imaging by combining the strengths of different imaging techniques to provide more comprehensive information in the clinical setting.

Indexed as

Liver DiseasesStem Cell TransplantationGenes, ReporterHumansMagnetic Resonance ImagingCell-tracking technologyChronic liver diseasesStem cell therapyStem cell-tracking

Identifiers

PMID37993759
OpenAlexW4388893692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.