ArticleNature2023
Trans-vaccenic acid reprograms CD8
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
18.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 115 citations in OpenAlex.
- Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.Signal transduction and targeted therapy · 2026Review
- Metabolic insights into the pathophysiology of tuberculous meningitis in FFPE postmortem human brain tissue.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- The interplay between lipid metabolism, cancer progression and anti-cancer immunity.Experimental & molecular medicine · 2026Review
- Synthesis of Cyclopropene-Modified Fatty Acids Allows Single-Cell Quantification of Uptake by Immune Cells.Angewandte Chemie (International ed. in English) · 2026Article
- Regulation of PD-1PD-L1 Immune Checkpoints by Gut Microbiota Metabolites and Their Clinical Translational Research: A Review.Immunity, inflammation and disease · 2026Review
- Targeting DGAT1 reprograms lipid landscape and restores CD8⁺ T cell immunity in pancreatic cancer.Nature communications · 2026Article
- Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting.Science (New York, N.Y.) · 2026Article
- Metabolites as signalling molecules in the tumour immune microenvironment.Nature reviews. Immunology · 2026Review
- Dietary supplementation with the hexane fraction of Ulva fasciata extract improves growth performance, immune responses, and antioxidant status in Nile tilapia (Oreochromis niloticus).Fish physiology and biochemistry · 2026Article
- Diet and Medicinal Herbs as Adjunctive Approaches to Immune Homeostasis in Sjögren's Disease.International journal of molecular sciences · 2026Review
- Spatial instruction of tissue immunity.ImmunoHorizons · 2026Review
- Review
- Repurposing rosmarinic acid as an anti-colorectal cancer agent through bolstering T cell anti-tumor immunity by enhancing activation of MEK1-mediated TCR signaling.Cancer immunology, immunotherapy : CII · 2026Article
- Metabolic dysregulation reshapes the immune landscape: The gut microbiota-mTOR axis in respiratory viral infection immunity.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Review
- Nutritional modulation of metabolic signaling within the tumor microenvironment for cancer therapy.Molecular and cellular biochemistry · 2026Review
- Regulators of CD8Nature reviews. Immunology · 2026Review
- Microbial-derived immunostimulatory small molecule augments anti-PD-1 therapy in lung cancer.Cell reports. Medicine · 2026Article
- LSD1 Inhibition Induces MHC-I and Dendritic Cell Activation to Promote Antitumor Immunity in Head and Neck Squamous Cell Carcinoma.Cancer research · 2026Article
- GPR43 alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome activation via β-arrestin 2.Biology direct · 2026Article
- Oleic acid alleviates the pathogenesis of lupus by suppressing the activation of TLR signaling pathways through the STAT3/IL-10 axis.Scientific reports · 2026Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors at 5 institutions in 2 countries.
Hao Fan *Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.ORCID 0000-0001-5245-9698
Siyuan Xia *Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.ORCID 0000-0001-6756-3519
Junhong Xiang *Department of Chemistry, The University of Chicago, Chicago, IL, USA.
Yuancheng LiWinship Cancer Institute, Emory University, Atlanta, GA, USA.
Matthew O RossDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.ORCID 0000-0003-2115-9806
Seon Ah LimDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-6560-4874
Fan YangDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Jiayi TuDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Lishi XieDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Urszula DoughertyDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Freya Q ZhangDepartment of Medicine, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-2596-0433
Zhong ZhengDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Rukang ZhangDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
Rong WuDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
Lei DongDepartment of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Rui SuDepartment of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA.ORCID 0000-0002-4807-6229
Xiufen ChenDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Thomas AlthausDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Peter A RiedellDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Patrick B JonkerThe Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Alexander MuirThe Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Gregory B LesinskiDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
Sarwish RafiqDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.ORCID 0000-0002-9295-3065
Madhav V DhodapkarDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
Wendy StockDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Olatoyosi OdenikeDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Anand A PatelDepartment of Medicine, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-0296-8686
Joseph OpfermanDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-1147-5621
Takemasa TsujiDepartment of Obstetrics and Gynecology, The University of Chicago, Chicago, IL, USA.ORCID 0000-0001-7563-2211
Junko MatsuzakiDepartment of Obstetrics and Gynecology, The University of Chicago, Chicago, IL, USA.
Hardik ShahDepartment of Medicine, The University of Chicago, Chicago, IL, USA.ORCID 0000-0001-8408-5686
Brandon FaubertDepartment of Medicine, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-2886-886X
Shannon E ElfThe Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Brian LaydenDepartment of Medicine, University of Illinois Chicago, Chicago, IL, USA.
B Marc BissonnetteDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Yu-Ying HeDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Justin KlineDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Hui MaoWinship Cancer Institute, Emory University, Atlanta, GA, USA.ORCID 0000-0002-0147-6022
Kunle OdunsiDepartment of Obstetrics and Gynecology, The University of Chicago, Chicago, IL, USA.
Xue GaoDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
Hongbo ChiDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA. hongbo.chi@stjude.org.ORCID 0000-0002-9997-2496
Chuan HeDepartment of Chemistry, The University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.ORCID 0000-0003-4319-7424
Jing ChenDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA. jingchen@uchicago.edu.ORCID 0000-0002-5376-9062
University of Chicago · USEmory University · USSt. Jude Children's Research Hospital · USCity of Hope · USUniversity of Illinois Chicago · US
Funding
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8MMulti-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5MLabeling and sequencing of 5hmC and 5mC in DNA-RenewalR01HG006827 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2012 to 2025
$7.2MTyrosine Kinase Signaling in Cancer Cell MetabolismR01CA140515 · NCI · UNIVERSITY OF CHICAGO · PI Jing Chen · 2010 to 2026
$5.4MSignaling and Targeting of 6-Phosphogluconate Dehydrogenase in Human CancersR01CA174786 · NCI · UNIVERSITY OF CHICAGO · PI CHEN, JING · 2014 to 2024
$3.7MProbing short and long term consequences of Small and Large Bowel Microbiota Transplants on Host Physiology: Implications for the development of future live biotherapeuticsR01DK138072 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG, Kristina Brooke Martinez-Guryn · 2024 to 2026
$2.1MDietary trans-vaccenic acid enhances anti-tumor immunityR01CA276568 · NCI · UNIVERSITY OF CHICAGO · PI Jing Chen · 2023 to 2026
$1.5MHeavy metal-stimulated signal transduction: new metal-regulatory and -responsive mechanismsK99ES034084 · NIEHS · UNIVERSITY OF CHICAGO · PI ROSS, MATTHEW OLIVER · 2023 to 2023
$88kNCI NIH HHS R01 CA140515NCI NIH HHS R01 CA174786NCI NIH HHS R01 CA276568NCI NIH HHS T32 CA009594NHGRI NIH HHS R01 HG006827NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK138072NIEHS NIH HHS K99 ES034084
Abstract
Diet-derived nutrients are inextricably linked to human physiology by providing energy and biosynthetic building blocks and by functioning as regulatory molecules. However, the mechanisms by which circulating nutrients in the human body influence specific physiological processes remain largely unknown. Here we use a blood nutrient compound library-based screening approach to demonstrate that dietary trans-vaccenic acid (TVA) directly promotes effector CD8
Indexed as
CD8-Positive T-LymphocytesNeoplasmsOleic AcidsAnimalsCattleCyclic AMPCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinDairy ProductsFatty Acids, VolatileHumansLinoleic Acids, ConjugatedMiceMilkReceptors, G-Protein-CoupledRed Meat11-octadecenoic acid9,11-linoleic acidCyclic AMPCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinFatty Acids, VolatileFFAR2 protein, humanLinoleic Acids, ConjugatedOleic AcidsReceptors, G-Protein-Coupled
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.