Evidence map›Paper›PMID 37993711›Full record

ArticleNature2023

Sequential appetite suppression by oral and visceral feedback to the brainstem.

Truong Ly, Jun Y Oh, Nilla Sivakumar, Sarah Shehata, Naymalis La Santa Medina, Heidi Huang, Zhengya Liu, Wendy Fang, Chris Barnes, Naz Dundar and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 82 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Nucleus of the solitary tract regulation of cue-induced appetitive behaviors via midbrain dopamine neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  5. Article
  6. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Functional segregation of body-brain signals in the area postrema.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Cellular coding of ingestion in the caudal brainstem.bioRxiv : the preprint server for biology · 2026
    Article
  16. Brain Nutrient Sensing: A Unifying Framework.Annual review of physiology · 2026
    Review
  17. GLP-1 physiology and pharmacology along the gut-brain axis.The Journal of clinical investigation · 2026
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Truong LyDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Jun Y OhHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Nilla SivakumarDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Sarah ShehataHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Naymalis La Santa MedinaHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Heidi HuangHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Zhengya LiuDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0009-0001-2352-3141
Wendy FangHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Chris BarnesHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Naz DundarDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Brooke C JarvieDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Anagh RaviDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Olivia K BarnhillDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Chelsea LiHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Grace R LeeHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Jaewon ChoiHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Heeun JangDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Zachary A KnightDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA. zachary.knight@ucsf.edu.ORCID 0000-0001-7621-1478
Howard Hughes Medical Institute · USUniversity of California, San Francisco · US

Funding

UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALKA M. KANAYA · 2015 to 2026
$14.6M
Neural Dynamics Underlying FeedingR01DK106399 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Zachary A. Knight · 2015 to 2026
$4.8M
Predoctoral Training in NeurobiologyT32NS115706 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAMUEL JEREMY PLEASURE · 2020 to 2026
$3.4M
Neural mechanisms linking need to rewardR01NS116626 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BERKE, JOSHUA D, KNIGHT, ZACHARY A. · 2023 to 2024
$1.7M
Investigating how long-term signals modulate brainstem satiation circuitsF31DK137586 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LY, TRUONG · 2023 to 2025
$134k
NIDDK NIH HHS F31 DK137586NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK106399NINDS NIH HHS R01 NS116626NINDS NIH HHS T32 NS115706
6 · The paper itself

Abstract

The termination of a meal is controlled by dedicated neural circuits in the caudal brainstem. A key challenge is to understand how these circuits transform the sensory signals generated during feeding into dynamic control of behaviour. The caudal nucleus of the solitary tract (cNTS) is the first site in the brain where many meal-related signals are sensed and integrated

Indexed as

Appetite RegulationBrain StemEatingFeedback, PhysiologicalFoodSatiationStomachAnimalsMiceNeural PathwaysNeuronsProlactin-Releasing HormoneSolitary NucleusTasteTime FactorsProlactin-Releasing Hormone

Identifiers

PMID37993711
PMCPMC10700140
OpenAlexW4388896472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.