Evidence map›Paper›PMID 37993596›Full record

ArticleCommunications biology2023

Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II.

Neville Magielse, Roberto Toro, Vanessa Steigauf, Mahta Abbaspour, Simon B Eickhoff, Katja Heuer, Sofie L Valk

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Neville MagielseInstitute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Wilhelm-Johnen-Straße, 52428, Jülich, Germany. n.magielse@fz-juelich.de.ORCID 0000-0002-6777-4225
Roberto ToroInstitut Pasteur, Unité de Neuroanatomie Appliquée et Théorique, Université Paris Cité, 25 rue du Dr. Roux, 75724, Paris, France.ORCID 0000-0002-6671-858X
Vanessa SteigaufDepartment of Biology, Northern Michigan University, 1401 Presque Isle Ave, MI, 49855, Marquette, USA.
Mahta AbbaspourBerlin School of Mind and Brain, Humboldt-Universität zu Berlin, Luisenstraße 56, Haus 1, 10117, Berlin, Germany.
Simon B EickhoffInstitute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Wilhelm-Johnen-Straße, 52428, Jülich, Germany.
Katja Heuer *Institut Pasteur, Unité de Neuroanatomie Appliquée et Théorique, Université Paris Cité, 25 rue du Dr. Roux, 75724, Paris, France.ORCID 0000-0002-7237-0196
Sofie L Valk *Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Wilhelm-Johnen-Straße, 52428, Jülich, Germany. s.valk@fz-juelich.de.ORCID 0000-0003-2998-6849
Forschungszentrum Jülich · DEInstitut Pasteur · FRHumboldt-Universität zu Berlin · DENorthern Michigan University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reciprocal connections between the cerebellum and the cerebrum have been suggested to simultaneously play a role in brain size increase and to support a broad array of brain functions in primates. The cerebello-cerebral system has undergone marked functionally relevant reorganization. In particular, the lateral cerebellar lobules crura I-II (the ansiform) have been suggested to be expanded in hominoids. Here, we manually segmented 63 cerebella (34 primate species; 9 infraorders) and 30 ansiforms (13 species; 8 infraorders) to understand how their volumes have evolved over the primate lineage. Together, our analyses support proportional cerebellar-cerebral scaling, whereas ansiforms have expanded faster than the cerebellum and cerebrum. We did not find different scaling between strepsirrhines and haplorhines, nor between apes and non-apes. In sum, our study shows primate-general structural reorganization of the ansiform, relative to the cerebello-cerebral system, which is relevant for specialized brain functions in an evolutionary context.

Indexed as

CerebellumPrimatesAnimalsBiological EvolutionBrainPhylogeny

Identifiers

PMID37993596
PMCPMC10665558
OpenAlexW4388912883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.