Evidence map›Paper›PMID 37993500›Full record

ArticleScientific reports2023

Monte Carlo based dosimetry of extraoral photobiomodulation for prevention of oral mucositis.

Anna N Yaroslavsky, Tyler W Iorizzo, Amy F Juliano, Ather Adnan, James D Carroll, Stephen T Sonis, Christine N Duncan, Wendy B London, Nathaniel S Treister

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Intraoral vs. extraoral photobiomodulation therapy for oral mucositis in head and neck cancer patients: a multicenter, randomized, single-blind clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  2. Article
  3. Review
  4. Article
  5. Photobiomodulation therapy.JADA foundational science · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Anna N YaroslavskyAdvanced Biophotonics Laboratory, Department of Physics and Applied Physics, University of Massachusetts Lowell, Lowell, MA, 01854, USA. ayaroslavsky@mgh.harvard.edu.
Tyler W IorizzoAdvanced Biophotonics Laboratory, Department of Physics and Applied Physics, University of Massachusetts Lowell, Lowell, MA, 01854, USA.
Amy F JulianoDepartment of Radiology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, 02114, USA.
Ather AdnanCollege of Medicine, Texas A&M Health Science Center, Houston, TX, 77030, USA.
James D CarrollTHOR Photomedicine, Amersham, HP7 9FB, UK.
Stephen T SonisDepartment of Surgery, Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, 02114, USA.
Christine N DuncanDepartment of Pediatrics, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, 02114, USA.
Wendy B LondonDepartment of Pediatrics, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, 02114, USA.ORCID 0000-0003-3571-6538
Nathaniel S TreisterDepartment of Surgery, Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, 02114, USA. ntreister@bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USUniversity of Massachusetts Lowell · USMassachusetts Eye and Ear Infirmary · USTexas A&M Health Science Center · US

Funding

Extraorally delivered lo level light therapy for prevention of oropharyngeal mucositis in pediatric patients undergoing hematopoietic stem cell transplantationR34DE025908 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI DUNCAN, CHRISTINE NOEL, TREISTER, NATHANIEL S · 2016 to 2016
$322k
NIDCR NIH HHS R34 DE025908
6 · The paper itself

Abstract

Photobiomodulation therapy (PBMT) is recommended for prevention and treatment of oral mucositis, a painful condition that occurs in cancer patients. Intraoral PBMT is limited to treating distal oral mucosa and oropharynx. Extraoral PBMT may provide a more efficient intervention. The goal of this study was to develop a clinically viable protocol for extraoral PBMT. Monte Carlo modeling was used to predict the distribution of 850 nm light for four treatment sites, using anatomical data obtained from MRI and optical properties from the literature. Simulated incident light power density was limited to 399 mW/cm

Indexed as

Low-Level Light TherapyNeoplasmsStomatitisHumansMonte Carlo MethodRadiometry

Identifiers

PMID37993500
PMCPMC10665335
OpenAlexW4388900993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.