Evidence map›Paper›PMID 37993163›Full record

ArticleBMJ open2023

Association between white blood cell count and adverse pregnancy outcomes: a retrospective cohort study from a tertiary hospital in China.

Yu Zhang, Yiling Qian, Chuanwei Liu, Xiaofang Fan, Xuesong Li, Yuping Song, Yujuan Fan, Zheng Hu, Jialin Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yu Zhang *Department of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-7446-8701
Yiling Qian *Department of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, China.
Chuanwei Liu *Department of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, China.
Xiaofang FanDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, China.
Xuesong LiDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, China.
Yuping SongDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, China.
Yujuan FanDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, China.
Zheng HuDepartment of Obstetrics and Gynecology, Minhang Hospital, Fudan University, Shanghai, China.
Jialin YangDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, China jialin_yang@fudan.edu.cn.ORCID 0000-0001-6767-9028
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to clarify the relationship between white blood cell (WBC) and adverse pregnancy outcomes.

designA total of 25 270 pregnant women underwent peripheral blood white blood cell count tests in the first, second and third trimesters. Adverse pregnancy outcomes were gestational hypertension, pre-eclampsia, gestational diabetes mellitus, preterm birth, low birth weight, caesarean delivery, macrosomia and fetal distress. Due to acute infectious disease or other diseases, 1127 were excluded.

settingMinhang Hospital, China.

participantsA total of 24 143 pregnant women were included in this study. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the adverse pregnancy outcomes.

resultsFor the 24 143 participants, we calculated adjusted ORs for adverse pregnancy outcomes associated with an increased WBC count. For gestational hypertension, the ORs were 1.18 (95% CI, 1.05 to 1.24) in the first trimester and 1.10 (1.06 to 1.13) in the second trimester; for pre-eclampsia, ORs were 1.14 (95% CI, 1.47 to 1.64) in the first trimester and 1.10 (1.05 to 1.16) in the second trimester; for gestational diabetes mellitus, ORs were 1.06 (95% CI, 1.00 to 1.13) in the first trimester and 1.10 (1.04 to 1.16) in the second trimester; for preterm birth, ORs were 1.12 (95% CI, 1.06 to 1.18) in the first trimester, 1.10 (1.06 to 1.13) in the second trimester and 1.12 (1.09 to 1.15) in the third trimester; for low birth weight, ORs were 1.09 (95% CI, 1.02 to 1.17) in the first trimester, 1.03 (0.99 to 1.08) in the second trimester and 1.12 (1.08 to 1.16) in the third trimester. Significant associations were not observed obviously for caesarean delivery, macrosomia and fetal distress.

conclusionsOur results indicate strong, continuous associations of maternal WBC count with increased risks of adverse pregnancy outcomes.

Indexed as

Diabetes, GestationalHypertension, Pregnancy-InducedPre-EclampsiaPremature BirthFemaleFetal DistressFetal MacrosomiaHumansInfant, NewbornLeukocyte CountPregnancyPregnancy OutcomeRetrospective StudiesTertiary Care CentersWeight GainFetal medicineMaternal medicineOther metabolic, e.g. iron, porphyria

Identifiers

PMID37993163
PMCPMC10668327
OpenAlexW4388914479

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.