ArticleNeuroImage. Clinical2023
Testing the triple network model of psychopathology in a transdiagnostic neurodevelopmental cohort.
Article in NeuroImage. Clinical, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Prefrontal Transcranial Direct Current Stimulation in Pediatric Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial.JAMA network open · 2025Trial
- The topology of adolescent mental health.medRxiv : the preprint server for health sciences · 2026Article
- Emotion Regulation in the Preadolescent Brain and the Role of Individual Temperamental Differences.Brain and behavior · 2025Article
- Multidimensional components of impulsivity during early adolescence: Relationships with brain networks and future substance-use in the Adolescent Brian and Cognitive Development (ABCD) study.bioRxiv : the preprint server for biology · 2025Article
- The relationship between neuromagnetic networks and cognitive impairment in self-limited epilepsy with centrotemporal spikes.Epilepsia open · 2025Article
- Triple network dynamics and future alcohol consumption in adolescents.Alcohol, clinical & experimental research · 2025Article
- Social pain is associated with altered developmental trajectories of connectivity among the triple network model of psychopathology.Social cognitive and affective neuroscience · 2025Article
- A study of dynamic functional connectivity changes in flight trainees based on a triple network model.Scientific reports · 2025Article
- Brain Function Characteristics of Children with Attention-Deficit/Hyperactivity Disorder Aged 4-9 Years During a GO/NOGO Task: An Functional Near-Infrared Spectroscopy Study.Neuropsychiatric disease and treatment · 2024Article
- Neurodevelopment of the functional connectivity of the salience network in facial emotion recognition from adolescence to adulthood.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
aimThe triple network model of psychopathology posits that altered connectivity between the Salience (SN), Central Executive (CEN), and Default Mode Networks (DMN) may underlie neurodevelopmental conditions. However, this has yet to be tested in a transdiagnostic sample of young people.
methodWe investigated this in 175 children (60 girls) that represent a heterogeneous population who are experiencing neurodevelopmental difficulties in cognition and behavior, and 60 comparison children (33 girls). Hyperactivity/impulsivity and inattention were assessed by parent-report. Resting-state functional Magnetic Resonance Imaging data were acquired and functional connectivity was calculated between independent network components and regions of interest. We then examined whether connectivity between the SN, CEN and DMN was dimensionally related to hyperactivity/impulsivity and inattention, whilst controlling for age, gender, and motion.
resultsHyperactivity/impulsivity was associated with increased functional connectivity between the SN, CEN, and DMN in at-risk children, whereas it was associated with decreased functional connectivity between the CEN and DMN in comparison children. These effects replicated in an adult parcellation of brain function and when using increasingly stringent exclusion criteria for in-scanner motion.
conclusionTriple network connectivity characterizes transdiagnostic neurodevelopmental difficulties with hyperactivity/impulsivity. We suggest that this may arise from delayed network segregation, difficulties sustaining CEN activity to regulate behavior, and/or a heightened developmental mismatch between neural systems implicated in cognitive control relative to those implicated in reward/affect processing.
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