Evidence map›Paper›PMID 37992314›Full record

ArticleAutophagy2024

Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulation.

Karolina Pierzynowska, Magdalena Podlacha, Lidia Gaffke, Estera Rintz, Karolina Wiśniewska, Zuzanna Cyske, Grzegorz Węgrzyn

Open access · hybridAbstract read
In one paragraph

Article in Autophagy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Silmitasertib, an FDA-designated orphan CK2 inhibitor, ameliorates neuropathology and motor dysfunction in a Huntington's disease mouse model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Karolina PierzynowskaDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.ORCID 0000-0003-3634-6567
Magdalena PodlachaDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.ORCID 0000-0002-7709-5955
Lidia GaffkeDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.ORCID 0000-0002-0820-7204
Estera RintzDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.ORCID 0000-0003-4941-766X
Karolina WiśniewskaDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Zuzanna CyskeDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Grzegorz WęgrzynORCID 0000-0003-4042-7466
University of Gdańsk · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington disease (HD) is a neurodegenerative disorder caused by a mutation in the

Indexed as

AutophagyForkhead Box Protein O3GenisteinHuntington DiseaseAnimalsBehavior, AnimalBrainDisease Models, AnimalHumansHuntingtin ProteinMiceMice, TransgenicForkhead Box Protein O3FoxO3 protein, mouseGenisteinHuntingtin ProteinAutophagy activationcorrection of neurodegenerative disease symptomsFOXO3genistein (4′,5,7-trihydroxyisoflavone)huntington disease mouse model

Identifiers

PMID37992314
PMCPMC11135876
OpenAlexW4388892541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.