Evidence map›Paper›PMID 37992296›Full record

ArticleNucleic acids research2024

Expression Atlas update: insights from sequencing data at both bulk and single cell level.

Nancy George, Silvie Fexova, Alfonso Munoz Fuentes, Pedro Madrigal, Yalan Bi, Haider Iqbal, Upendra Kumbham, Nadja Francesca Nolte, Lingyun Zhao, Anil S Thanki and 21 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
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  3. Computational modelling of cell identity.The Biochemical journal · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Nancy GeorgeEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.ORCID 0000-0003-4183-8865
Silvie FexovaEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Alfonso Munoz FuentesEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Pedro MadrigalEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Yalan BiEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Haider IqbalEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Upendra KumbhamEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Nadja Francesca NolteEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Lingyun ZhaoEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Anil S ThankiEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Iris D YuEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Jose C Marugan CallesEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Karoly ErdosEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Liora VilmovskyEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Sandeep R KurriEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Anna Vathrakokoili-PournaraEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.ORCID 0000-0002-2701-1987
David Osumi-SutherlandEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Ananth PrakashEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Shengbo WangEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Marcela K Tello-RuizCold Spring Harbour Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Sunita KumariCold Spring Harbour Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Doreen WareCold Spring Harbour Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.ORCID 0000-0002-8125-3821
Damien Goutte-GattatFlyBase-Cambridge, Department of Physiology, Development and Neuroscience, University of Cambridge Downing Street, Cambridge CB2 3DY, UK.ORCID 0000-0002-6095-8718
Yanhui HuPerrimon Lab, Department of Genetics, Harvard Medical School, Boston MA 02115, USA.ORCID 0000-0003-1494-1402
Nick BrownFlyBase-Cambridge, Department of Physiology, Development and Neuroscience, University of Cambridge Downing Street, Cambridge CB2 3DY, UK.
Norbert PerrimonPerrimon Lab, Department of Genetics, Harvard Medical School, Boston MA 02115, USA.
Juan Antonio VizcaínoEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Tony BurdettEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Sarah TeichmannWellcome Trust Sanger Institute. Wellcome Genome Campus, Hinxton CB10 1SA, UK.
Alvis BrazmaEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.
Irene PapatheodorouEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton CB10 1SD, UK.

Funding

Wellcome TrustWellcome Trust 108437/Z/15/Z
6 · The paper itself

Abstract

Expression Atlas (www.ebi.ac.uk/gxa) and its newest counterpart the Single Cell Expression Atlas (www.ebi.ac.uk/gxa/sc) are EMBL-EBI's knowledgebases for gene and protein expression and localisation in bulk and at single cell level. These resources aim to allow users to investigate their expression in normal tissue (baseline) or in response to perturbations such as disease or changes to genotype (differential) across multiple species. Users are invited to search for genes or metadata terms across species or biological conditions in a standardised consistent interface. Alongside these data, new features in Single Cell Expression Atlas allow users to query metadata through our new cell type wheel search. At the experiment level data can be explored through two types of dimensionality reduction plots, t-distributed Stochastic Neighbor Embedding (tSNE) and Uniform Manifold Approximation and Projection (UMAP), overlaid with either clustering or metadata information to assist users' understanding. Data are also visualised as marker gene heatmaps identifying genes that help confer cluster identity. For some data, additional visualisations are available as interactive cell level anatomograms and cell type gene expression heatmaps.

Indexed as

Databases, GeneticGene Expression ProfilingProteomicsAnimalsGenotypeHumansInternetMetadataSingle-Cell Analysis

Identifiers

PMID37992296
PMCPMC10767917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.