Evidence map›Paper›PMID 37992238›Full record

ArticleSchizophrenia bulletin2024

A Cross-sectional Conceptual Replication and Longitudinal Evaluation of the PANSS-Autism-Severity-Score Measure Suggests it Does Not Capture Autistic Traits in Individuals With Psychosis.

Katharine Chisholm, Frederike Schirmbeck, Amy E Pinkham, Noah J Sasson, Claudia J P Simons, Lieuwe de Haan, Philip D Harvey, David L Penn, Tim Ziermans

Abstract read
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In one paragraph

Article in Schizophrenia bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. What autism features in first episode psychosis? Results from a 2-year follow-up study.European archives of psychiatry and clinical neuroscience · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katharine ChisholmSchool of Psychology, Institute of Health and Neurodevelopment, Aston University, Aston St, Birmingham, B4 7ET, UK.ORCID 0000-0002-0575-0789
Frederike SchirmbeckDepartment of Psychiatry, Amsterdam University Medical Center, Meibergdreef, University of Amsterdam, Amsterdam, The Netherlands.
Amy E PinkhamDepartment of Psychology, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA.ORCID 0000-0003-2803-4520
Noah J SassonDepartment of Psychology, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA.
Claudia J P SimonsDepartment of Psychiatry and Neuropsychology, Maastricht University Medical Center, School for Mental Health and Neuroscience, Maastricht, The Netherlands.ORCID 0000-0002-7637-3589
Lieuwe de HaanDepartment of Psychiatry, Amsterdam University Medical Center, Meibergdreef, University of Amsterdam, Amsterdam, The Netherlands.
Philip D HarveyDepartment of Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, FL, USA.
David L PennDepartment of Psychology and Neuroscience, University of North Carolina, Chapel Hill, USA.
Tim ZiermansDepartment of Psychology, Dutch Autism & ADHD Research Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-5224-1365

Funding

Social Cognition Psychometric EvaluationR01MH093432 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARVEY, PHILIP D., PENN, DAVID LEWIS · 2012 to 2016
$3.2M
Dutch Health Research Council 10-000-1001NIH HHS RO1 MH093432NIMH NIH HHS R01 MH093432
6 · The paper itself

Abstract

backgroundAutism and psychosis co-occur at elevated rates, with implications for clinical outcomes, functioning, and suicidality. The PANSS-Autism-Severity-Score (PAUSS) is a measure of autism trait severity which has not yet been validated externally or longitudinally. STUDY

designParticipants were derived from the GROUP and SCOPE datasets. Participants included 1448 adults with schizophrenia spectrum disorder (SSD), 800 SSD-siblings, 103 adults diagnosed with an autistic spectrum condition (ASC), and 409 typically-developing controls (TC). Analyses from the original validation study were conducted with SSD participants, and extended into ASC, SSD-sibling, and TC participants. Test-retest reliability of the PAUSS at 2-weeks and long-term stability 3 and 6-years was also examined. STUDY

resultsResults differed in important ways from the original validation. SSD participants reported higher PAUSS scores than other groups, with only a fraction of ASC participants scoring as "PAUSS-Autistic." Cronbach's alpha was acceptable for the SSD cohort only. Two-week stability of the PAUSS was fair to good for all PAUSS scores. Long-term stability was poor for most PAUSS items but fair for total PAUSS score.

conclusionsResults suggest that the PAUSS does not appear appropriate for assessing autism, with the low rate of PAUSS-Autistic in the ASC population suggesting the PAUSS may not accurately reflect characteristics of autism. The relative lack of long-term stability is cause for concern and suggestive that the PAUSS is capturing features of psychosis rather than autism traits.

Indexed as

Autism Spectrum DisorderPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSeverity of Illness IndexAdultComorbidityCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedReproducibility of ResultsYoung Adult“Autistic traits”“Measure validation”PANSSPsychosis“Schizophrenia spectrum disorders”

Identifiers

PMID37992238
PMCPMC11661953

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.