Evidence map›Paper›PMID 37991948›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The mechanism of

Maria E Falzone, Roderick MacKinnon

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and GαProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. MAPK signaling and angiopoietin-2 contribute to endothelial permeability in capillary malformations.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. APurinergic signalling · 2025
    Article
  12. An integrated mechanism of GProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria E FalzoneLaboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, NY 10065.ORCID 0000-0001-6738-7017
Roderick MacKinnonLaboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, NY 10065.
Rockefeller University · US

Funding

Activation of phospholipase C beta enzymes by G beta-gamma and corresponding regulation of downstream ion channelsF32GM142137 · NIGMS · ROCKEFELLER UNIVERSITY · PI FALZONE, MARIA ELIZABETH · 2021 to 2023
$205k
NIGMS NIH HHS F32 GM142137
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

GTP-Binding ProteinsPhosphatidylinositolsHydrolysisPhospholipase C betaGTP-Binding ProteinsPhosphatidylinositolsPhospholipase C betaGPCR signalingGαqGβγPIP2PLCβ3

Identifiers

PMID37991948
PMCPMC10691244
OpenAlexW4388895493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.