Evidence map›Paper›PMID 37991701›Full record

ArticleRadiological physics and technology2024

Gold nanoparticles conjugated with epidermal growth factor and gadolinium for precision delivery of contrast agents in magnetic resonance imaging.

Suélio M Queiroz, Thaís S Veriato, Leandro Raniero, Maiara L Castilho

Abstract read
PubMed Publisher
In one paragraph

Article in Radiological physics and technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Suélio M QueirozBionanotechnology Laboratory, Research and Development Institute, University of Vale do Paraíba, São José dos Campos, São Paulo, 12244000, Brazil.
Thaís S VeriatoBionanotechnology Laboratory, Research and Development Institute, University of Vale do Paraíba, São José dos Campos, São Paulo, 12244000, Brazil.
Leandro RanieroNanosensors Laboratory, Research and Development Institute, University of Vale do Paraiba, Sao Jose dos Campos, Sao Paulo, 12244000, Brazil.
Maiara L CastilhoBionanotechnology Laboratory, Research and Development Institute, University of Vale do Paraíba, São José dos Campos, São Paulo, 12244000, Brazil. mcastilho@univap.br.ORCID http://orcid.org/0000-0002-8410-0302
Universidade do Vale do Paraíba · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 302994/2018-4Conselho Nacional de Desenvolvimento Científico e Tecnológico 427602/2018-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/23898-6
6 · The paper itself

Abstract

The utilization of contrast agents in magnetic resonance imaging (MRI) has become increasingly important in clinical diagnosis. However, the low diagnostic specificity of this technique is a limiting factor for the early detection of tumors. To develop a new contrast agent with a specific target for early stage tumors, we present the synthesis and characterization of a nanocontrast composed of gold nanoparticles (AuNPs), gadopentetic acid (Gd-DTPA), and epidermal growth factor (EGF). Carbodiimide-based chemistry was utilized to modify Gd-DTPA for functionalization with AuNPs. This resulted in the formation of the Au@Gd-EGF nanocontrast. The relaxation rate (1/T1) of the nanocontrast was analyzed using MRI, and cytotoxicity was determined based on cell viability and mitochondrial activity in a human breast adenocarcinoma cell line. Fourier-transform infrared spectroscopy analysis confirmed the effectiveness of carbodiimide in the formation of the Gd-DTPA-cysteamine complex in the presence of bands at 930, 1042, 1232, 1588, and 1716 cm

Indexed as

Metal NanoparticlesNeoplasmsCarbodiimidesContrast MediaEpidermal Growth FactorGadoliniumGadolinium DTPAGoldHumansMagnetic Resonance ImagingCarbodiimidesContrast MediaEpidermal Growth FactorGadoliniumGadolinium DTPAGoldEpidermal growth factorGadopentetic acidGold nanoparticleMagnetic resonance imaging

Identifiers

PMID37991701
OpenAlexW4388900807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.