Evidence map›Paper›PMID 37991362›Full record

ArticleMicrobiology spectrum2024

Phosphoproteomic landscape of pseudorabies virus infection reveals multiple potential antiviral targets.

Zongyi Bo, Xiaojuan Li, Chengcheng Zhang, Mengjiao Guo, Yongzhong Cao, Xiaorong Zhang, Yantao Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zongyi Bo *Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University , Yangzhou, Jiangsu, China.ORCID 0000-0001-5286-7405
Xiaojuan Li *Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University , Yangzhou, Jiangsu, China.
Chengcheng ZhangJiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, College of Veterinary Medicine, Yangzhou University , Yangzhou, Jiangsu, China.
Mengjiao GuoJiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, College of Veterinary Medicine, Yangzhou University , Yangzhou, Jiangsu, China.
Yongzhong CaoJoint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University , Yangzhou, Jiangsu, China.
Xiaorong ZhangJiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, College of Veterinary Medicine, Yangzhou University , Yangzhou, Jiangsu, China.ORCID 0000-0003-2343-6811
Yantao WuJoint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University , Yangzhou, Jiangsu, China.ORCID 0000-0003-2647-395X

Funding

China Postdoctoral Science Foundation (China Postdoctoral Foundation Project) 2022M722693JST | Natural Science Foundation of Jiangsu Province (Jiangsu Natural Science Foundation) BK20210805MOST | National Natural Science Foundation of China (NSFC) 32102635
6 · The paper itself

Abstract

importancePseudorabies virus (PRV) is a kind of alpha herpesvirus that infects a wide range of animals and even human beings. Therefore, it is important to explore the mechanisms behind PRV replication and pathogenesis. By conducting a tandem mass tag-based phosphoproteome, this study revealed the phosphorylated proteins and cellular response pathways involved in PRV infection. Findings from this study shed light on the relationship between the phosphorylated cellular proteins and PRV infection, as well as guiding the discovery of targets for the development of antiviral compounds against PRV.

Indexed as

Herpesvirus 1, SuidPseudorabiesAnimalsAntiviral AgentsHumansVirus ReplicationAntiviral Agentsantiviral targetsphosphoproteomic landscapepseudorabies virusvirus-host interaction

Identifiers

PMID37991362
PMCPMC10783065

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.