Evidence map›Paper›PMID 37991143›Full record

ArticleEuropean stroke journal2024

Recanalization status and temporal evolution of early ischemic changes following stroke thrombectomy.

Pekka Virtanen, Liisa Tomppo, Georgios Georgiopoulos, Nina Brandstack, Erno Peltola, Tatu Kokkonen, Kimmo Lappalainen, Antti Korvenoja, Daniel Strbian

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Pekka VirtanenDepartment of Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0002-9547-4940
Liisa TomppoDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Georgios GeorgiopoulosDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece.
Nina BrandstackDepartment of Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Erno PeltolaDepartment of Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Tatu KokkonenDepartment of Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Kimmo LappalainenDepartment of Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Antti KorvenojaDepartment of Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Daniel StrbianDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0001-9095-2344
University of Helsinki · FIKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPresent-day computer tomography (CT) scanners have excellent spatial resolution and signal-to-noise ratio and are instrumental detecting early ischemic changes (EIC) in brain. We assessed the temporal changes of EIC based on the recanalization status after thrombectomy. PATIENTS AND

methodsThe cohort comprises consecutive patients with acute ischemic stroke in anterior circulation treated with thrombectomy in tertiary referral hospital. All baseline and follow-up scans were screened for any ischemic changes and further classified using Alberta Stroke Program Early CT Score (ASPECTS). Generalized linear mixed models were used to analyze the impact of recanalization status using modified Thrombolysis in Cerebral Infarction (mTICI) on temporal evolution of ischemic changes.

resultsWe included 614 patients with ICA, M1, or M2 occlusions. Median ASPECTS score was 9 (IQR 7-10) at baseline and 7 (5-8) at approximately 24 h. mTICI 3 was achieved in 207 (33.8%), 2B 241 (39.3%), 2A in 77 (12.6%), and 0-1 in 88 (14.3%) patients. Compared to patients with mTICI 3, those with mTICI 0-1 and 2A had less favorable temporal changes of ASPECTS (

conclusionsTemporal evolution of the ischemic changes and ASPECTS are related to the success of the recanalization therapy in cortical regions of ICA/M1 patients, but not in their deep brain structures or M2 patients. In none of the patients did EIC revert in any brain region after successful recanalization.

Indexed as

Ischemic StrokeThrombectomyAgedAged, 80 and overBrain IschemiaFemaleHumansMaleMiddle AgedTime FactorsTomography, X-Ray ComputedTreatment Outcomecomputed tomographyEarly ischemic signsrecanalizationthrombectomy

Identifiers

PMID37991143
PMCPMC11318421
OpenAlexW4388904246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.