ReviewJournal of magnetic resonance imaging : JMRI2024
Decoupling Between Brain Activity and Cerebrospinal Fluid Movement in Neurological Disorders.
Review in Journal of magnetic resonance imaging : JMRI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Transcranial direct current stimulation improves reduced global BOLD-CSF coupling in patients with insomnia disorder and comorbid anxiety: a resting-state functional MRI study.BMC psychiatry · 2026Trial
- Global brain activity links subcortical degeneration to cortical tau progressively across Braak regions over early Alzheimer's disease stages.Nature communications · 2026Article
- Noninvasive 3D mapping of tissue stress using reverberant shear wave.Nature communications · 2026Article
- Greater hypoxic burden predicts weaker coordination between brain pulsation and CSF flow on 7T MRI independent of non-hypoxic arousals: Implications for glymphatic activity.bioRxiv : the preprint server for biology · 2026Article
- Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sensory encoding and memory retrieval are coordinated with propagating waves in the human brain.Nature communications · 2026Article
- Resolving cognitive heterogeneity in white matter hyperintensities through integrated analyses of microbiome, metabolome, and brain glymphatic function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Global brain activity links subcortical degeneration to cortical tau progressively across Braak regions over early Alzheimer's disease stages.bioRxiv : the preprint server for biology · 2026Article
- Impact of neurovascular coupling and glymphatic function on cognitive function in asymptomatic cerebral small vessel disease.Frontiers in neurology · 2026Article
- Clearance mechanisms of the glymphatic/lymphatic system in the brain: new therapeutic perspectives for cognitive impairment.Cognitive neurodynamics · 2025Review
- Early menopause is associated with reduced global brain activity.bioRxiv : the preprint server for biology · 2025Article
- Temporal fluctuation in lateral ventricle volume and its coupling with CSF inflow and global BOLD signal.Scientific reports · 2025Article
- Patterns of pathological tau deposition reflect the dynamics of cortical brain activity.Cell reports · 2025Article
- Glymphatic Function as a Prognostic Biomarker in Prolonged Disorders of Consciousness.CNS neuroscience & therapeutics · 2025Article
- Glymphatic system dysfunction in chronic tinnitus patients with sleep disturbance.Frontiers in neurology · 2025Article
- Alterations in coupling between global brain activity and cerebrospinal fluid flow in patients with insomnia disorder before and after transcranial direct current stimulation: a resting-state functional MRI study.Frontiers in psychiatry · 2025Article
- Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Sex-specific age-related differences in cerebrospinal fluid clearance assessed by resting-state functional magnetic resonance imaging.NeuroImage · 2024Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Recent research has identified a link between the global mean signal of resting-state functional MRI (fMRI) and macro-scale cerebrospinal fluid movement, indicating the potential link between this resting-state dynamic and brain waste clearance. Consistent with this notion, the strength of this coupling has been associated with multiple neurodegenerative disease pathologies, especially the build-up of toxic proteins. This article aimed to review the latest advancements in this research area, emphasizing studies on spontaneous global brain activity that is tightly linked to the global mean resting-state fMRI signal, and aimed to discuss potential mechanisms through which this activity and associated physiological modulations might affect brain waste clearance. The available evidence supports the presence of a highly organized global brain activity that is linked to arousal and memory systems. This global brain dynamic, along with its associated physiological modulations, has the potential to influence brain waste clearance through multiple pathways through multiple pathways. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY: Stage 3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.