Evidence map›Paper›PMID 37991131›Full record

SynthesisClinical and translational science2023

Healthcare professionals' and consumers' knowledge, attitudes, perspectives, and education needs in oncology pharmacogenomics: A systematic review.

Chiao Xin Lim, Alistair Bozkurt, Zi Yue Chen, Abbey Hird, Joanne Wickens, Smaro Lazarakis, Safeera Y Hussainy, Marliese Alexander

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Clinical and translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Toward an integrated resource for pharmacogenomics (PGx): Survey findings from the genomic medicine communities.Genetics in medicine : official journal of the American College of Medical Genetics · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chiao Xin LimPharmacy, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.ORCID 0000-0001-5543-8411
Alistair BozkurtPharmacy, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.
Zi Yue ChenPharmacy, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.
Abbey HirdPharmacy, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.
Joanne WickensPharmacy, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.
Smaro LazarakisHealth Sciences Library, Royal Melbourne Hospital, Parkville, Victoria, Australia.ORCID 0000-0002-3618-9605
Safeera Y HussainyPharmacy Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0003-1418-8078
Marliese AlexanderPharmacy Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0001-5782-7912
RMIT University · AUThe University of Melbourne · AUThe Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical implementation of pharmacogenomic (PGx)-guided prescribing in oncology lags behind research evidence generation. We aimed to identify healthcare professionals' (HCPs) and consumers' knowledge, attitudes, perspectives, and education needs to inform strategies for implementation of scalable and sustainable oncology PGx programs. Systematic review of original articles indexed in EMBASE, EMCARE, MEDLINE, and PsycInfo from January 2012 until June 2022, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and using the Mixed Methods Appraisal Tool. PROSPERO registration number CRD42022352348. Of 1442 identified studies; 23 met inclusion criteria with 87% assessed high quality. Of these, 52% reported on HCPs, 35% on consumers, and 13% on both HCPs and consumers. Most were conducted in the United States (70%) and included multiple cancer types (74%). Across studies, HCPs and consumers mostly perceived value in PGx, however, both groups reported barriers to utilization, including cost, lack of consistent recommendations across guidelines, and limited knowledge among HCPs; test accuracy, clear testing benefits, and genomic information confidentiality among consumers. HCPs and consumers value and want to engage in PGx strategies in oncology care, however, are inhibited by unmet needs and practice and knowledge gaps. Implementation strategies aimed at addressing these issues may best support increased PGx uptake in oncology practice.

Indexed as

NeoplasmsPharmacogeneticsHealth Knowledge, Attitudes, PracticeHealth PersonnelHumansMedical Oncology

Identifiers

PMID37991131
PMCPMC10719462
OpenAlexW4388922110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.