Evidence map›Paper›PMID 37991093›Full record

ReviewJournal of magnetic resonance imaging : JMRI2024

Probing Renal Microstructure and Function with Advanced Diffusion MRI: Concepts, Applications, Challenges, and Future Directions.

Julia Stabinska, Hans-Jörg Wittsack, Lilach O Lerman, Alexandra Ljimani, Eric E Sigmund

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of magnetic resonance imaging : JMRI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Diffusion MRI of the Body: Beyond PGSE-EPI.Journal of magnetic resonance imaging : JMRI · 2026
    Review
  3. Article
  4. Article
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  9. Review
  10. Diffusion tensor imaging of the healthy feline kidney.Journal of feline medicine and surgery · 2026
    Article
  11. Article
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  15. Article
  16. Article
  17. Article
  18. Article
  19. Magnetic resonance imaging of renal oxygenation.Nature reviews. Nephrology · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Julia StabinskaF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.ORCID 0000-0003-2730-4250
Hans-Jörg WittsackDepartment of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich Heine University Düsseldorf, Dusseldorf, Germany.ORCID 0000-0002-5830-423X
Lilach O LermanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-3271-3887
Alexandra LjimaniDepartment of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich Heine University Düsseldorf, Dusseldorf, Germany.ORCID 0000-0002-9748-9927
Eric E SigmundBernard and Irene Schwartz Center for Biomedical Imaging Center for Advanced Imaging Innovation and Research (CAI2R), New York University Langone Health, New York City, New York, USA.ORCID 0000-0001-6783-3611
Heinrich Heine University Düsseldorf · DEAdvanced Imaging Research (United States) · USKennedy Krieger Institute · USMayo Clinic · US

Funding

Advanced Diffusion Imaging for Management of Renal Cancer: Oncologic Control and Renal Functional Reserve - Resubmission - 1R01CA245671 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHANDARANA, HERSH, SIGMUND, ERIC EDWARD · 2020 to 2025
$3.0M
Quantitative magnetization transfer MRI for evaluation of renal fibrosisR01DK122734 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2020 to 2023
$2.2M
Noninvasive Evaluation of Renal Allograft Fibrosis by MRIR21AG062104 · NIA · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2020 to 2021
$414k
Deutsche Forschungsgemeinschaft 497764939NCI NIH HHS R01 CA245671NCI NIH HHS R01CA245671NIA NIH HHS R21 AG062104NIA NIH HHS R21AG062104NIDDK NIH HHS R01 DK122734Research Committee of the Medical Faculty of Heinrich-Heine-University Düsseldorf 2020-65
6 · The paper itself

Abstract

Diffusion measurements in the kidney are affected not only by renal microstructure but also by physiological processes (i.e., glomerular filtration, water reabsorption, and urine formation). Because of the superposition of passive tissue diffusion, blood perfusion, and tubular pre-urine flow, the limitations of the monoexponential apparent diffusion coefficient (ADC) model in assessing pathophysiological changes in renal tissue are becoming apparent and motivate the development of more advanced diffusion-weighted imaging (DWI) variants. These approaches take advantage of the fact that the length scale probed in DWI measurements can be adjusted by experimental parameters, including diffusion-weighting, diffusion gradient directions and diffusion time. This forms the basis by which advanced DWI models can be used to capture not only passive diffusion effects, but also microcirculation, compartmentalization, tissue anisotropy. In this review, we provide a comprehensive overview of the recent advancements in the field of renal DWI. Following a short introduction on renal structure and physiology, we present the key methodological approaches for the acquisition and analysis of renal DWI data, including intravoxel incoherent motion (IVIM), diffusion tensor imaging (DTI), non-Gaussian diffusion, and hybrid IVIM-DTI. We then briefly summarize the applications of these methods in chronic kidney disease and renal allograft dysfunction. Finally, we discuss the challenges and potential avenues for further development of renal DWI. LEVEL OF EVIDENCE: 5 TECHNICAL EFFICACY: Stage 2.

Indexed as

Diffusion Magnetic Resonance ImagingKidneyAlgorithmsAnimalsHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedKidney Diseasesdiffusion kurtosis imagingdiffusion tensor imagingintravoxel incoherent motionkidneynon‐Gaussian diffusionrenal diffusion‐weighted imaging

Identifiers

PMID37991093
PMCPMC11117411
OpenAlexW4388922005

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.