Evidence map›Paper›PMID 37990960›Full record

ArticleJournal of cachexia, sarcopenia and muscle2024

Association of handgrip strength and walking pace with incident Parkinson's disease.

Mengyi Liu, Panpan He, Ziliang Ye, Yuanyuan Zhang, Chun Zhou, Sisi Yang, Yanjun Zhang, Xianhui Qin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mengyi LiuDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Panpan HeDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ziliang YeDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yuanyuan ZhangDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chun ZhouDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Sisi YangDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yanjun ZhangDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xianhui QinDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0001-7812-7982
National Clinical Research Center for Digestive Diseases · CN

Funding

National Key Research and Development Program 2022YFC2009600National Key Research and Development Program 2022YFC2009605National Natural Science Foundation of China 81730019National Natural Science Foundation of China 81973133Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University 2017J009
6 · The paper itself

Abstract

backgroundWe aimed to quantify the association of handgrip strength and self-reported walking pace with incident Parkinson's disease (PD) in the general population.

methodsA total of 419 572 participants (54.1% females, mean age: 56.1 years [SD, 8.2]) without prior PD were included from UK Biobank. Handgrip strength was assessed by dynamometer. Walking pace was self-reported as slow, average or brisk. The study outcome was incident PD, determined by self-report data, hospital admission records or death records.

resultsThe mean handgrip strength was 23.5 (SD, 6.3) and 39.6 (SD, 8.9) kg for females and males, respectively. A total of 33 645 (8.0%), 221 682 (52.8%) and 164 245 (39.2%) participants reported slow, average and brisk walking pace, respectively. Over a median follow-up duration of 12.5 years, 2152 participants developed incident PD. When handgrip strength was assessed as sex-specific tertiles, compared with those in the third tertile, the adjusted hazard ratios (HRs) (95% confidence interval [CI]) of incident PD for participants in the second and first tertiles were 1.23 (1.09-1.39) and 1.60 (1.42-1.79), respectively. Compared with brisk walking pace, average (HR, 1.33; 95% CI: 1.20-1.47) or slow (HR, 1.84; 95% CI: 1.57-2.15) walking pace was associated with a higher risk of incident PD. A lower grip strength (Tertiles 1 and 2) and an average/slow walking pace accounted for 23.8% and 19.9% of PD cases, respectively. When handgrip strength and walking pace were considered together, the highest risk of incident PD was observed in participants with both lowest handgrip strength and slow walking pace (HR, 2.89; 95% CI: 2.30-3.64). Genetic risks of PD did not significantly modify the relation of handgrip strength (P for interaction = 0.371) or walking pace (P for interaction = 0.082) with new-onset PD.

conclusionsLow handgrip strength and slow walking pace were significantly associated with a higher risk of incident PD, regardless of the individuals' genetic risk profile.

Indexed as

Parkinson DiseaseFemaleHand StrengthHumansMaleMiddle AgedRisk FactorsWalking Speedgenetic susceptibilityhandgrip strengthParkinson's diseaseUK Biobankwalking pace

Identifiers

PMID37990960
PMCPMC10834345
OpenAlexW4388922042

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.