Evidence map›Paper›PMID 37990800›Full record

ArticleNMR in biomedicine2024

Investigating the origin of the

Minjie Zhu, Aditya Jhajharia, Sonal Josan, Jae Mo Park, Yi-Fen Yen, Adolf Pfefferbaum, Ralph E Hurd, Daniel M Spielman, Dirk Mayer

Open access · hybridAbstract read
In one paragraph

Article in NMR in biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Metabolic Imaging of Hyperpolarized [1-International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Minjie ZhuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Aditya JhajhariaDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Sonal JosanDigital Health, Siemens Healthineers, Erlangen, Germany.
Jae Mo ParkAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-7404-6971
Yi-Fen YenMartinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-9986-5327
Adolf PfefferbaumDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Ralph E HurdDepartment of Radiology, Stanford University School of Medicine, Stanford, California, USA.
Daniel M SpielmanDepartment of Radiology, Stanford University School of Medicine, Stanford, California, USA.
Dirk MayerDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-7557-9019
Stanford University · USUniversity of Maryland, Baltimore · USAdvanced Imaging Research (United States) · USMassachusetts General Hospital · USSiemens (Germany) · DE

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolismR01NS107409 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PARK, JAE MO · 2020 to 2024
$2.7M
Metabolic imaging of nonalcoholic fatty liver diseaseR01DK106395 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2016 to 2019
$1.9M
Carbon-13 Polarizer for Metabolic MR ImagingS10OD021768 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2017 to 2017
$1.9M
Dynamic Metabolic Imaging of Hyperpolarized SubstratesR01EB009070 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2009 to 2012
$1.6M
A Proof-of-concept of Vitamin B3 for Metabolic MR ImagingR21GM137227 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2020 to 2021
$461k
Enzyme-enabled hyperpolarized 13C MRI for antibody-targeted imagingR21EB029083 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI KAO, JOSEPH PAO YUNG, MAYER, DIRK · 2020 to 2020
$425k
Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized 13C pyruvateR21NS096575 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2016 to 2017
$424k
Hyperpolarized 13C imaging of mitochondrial metabolism for improved characterization of prostate cancerR21CA213020 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK, SIDDIQUI, MOHUMMAD MINHAJ · 2017 to 2018
$369k
Exploiting Altered Porphyrin Synthesis for Metabolic Imaging of GlioblastomaR21CA202694 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI KAO, JOSEPH PAO YUNG, MAYER, DIRK · 2016 to 2017
$369k
NCATS NIH HHS UL1 TR003098NCI NIH HHS R21 CA202694NCI NIH HHS R21 CA213020NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB009070NIBIB NIH HHS R21 EB029083NIDDK NIH HHS R01 DK106395NIGMS NIH HHS R21 GM137227NIH HHS R01 DK106395NIH HHS R01 EB009070NIH HHS R01 NS107409NIH HHS R21 CA202694NIH HHS R21 CA213020NIH HHS R21 GM137227NIH HHS R21 NS096575NIH HHS S10 OD021768NINDS NIH HHS R01 NS107409NINDS NIH HHS R21 NS096575
6 · The paper itself

Abstract

The goal of this study was to investigate the origin of brain lactate (Lac) signal in the healthy anesthetized rat after injection of hyperpolarized (HP) [1-

Indexed as

Lactic AcidPyruvic AcidAnimalsBlood-Brain BarrierBrainCarbon IsotopesMagnetic Resonance ImagingRatsCarbon IsotopesLactic AcidPyruvic Acidblood-brain barrierbrain metabolismhyperpolarized 13Clactatepyruvaterat

Identifiers

PMID37990800
PMCPMC11184633
OpenAlexW4388922119

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.