Evidence map›Paper›PMID 37990697›Full record

ArticleActa medica Philippina2023

Lack of Methylation Changes in

Angelo Augusto M Sumalde, Ivana V Yang, Talitha Karisse L Yarza, Celina Ann M Tobias-Grasso, Ma Leah C Tantoco, Elizabeth Davidson, Abner L Chan, Mahshid S Azamian, Teresa Luisa G Cruz, Seema R Lalani and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta medica Philippina, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Angelo Augusto M SumaldeCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Ivana V YangDepartment of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus (CU-AMC), Aurora, Colorado, USA.
Talitha Karisse L YarzaPhilippine National Ear Institute, National Institutes of Health, University of the Philippines Manila, Manila, Philippines.
Celina Ann M Tobias-GrassoMED-EL, Innsbruck, Austria.
Ma Leah C TantocoDepartment of Otolaryngology-Head and Neck Surgery, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Elizabeth DavidsonDepartment of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus (CU-AMC), Aurora, Colorado, USA.
Abner L ChanCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Mahshid S AzamianDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Teresa Luisa G CruzCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Seema R LalaniDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Maria Rina T Reyes-QuintosDepartment of Otolaryngology-Head and Neck Surgery, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Eva Maria Cutiongco-de la PazNational Institutes of Health, University of the Philippines Manila, Manila, Philippines.
Regie Lyn P Santos-CortezDepartment of Otolaryngology - Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus (CU-AMC), Aurora, Colorado, USA.ORCID 0000-0002-9958-2535
Charlotte M ChiongCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Philippine General Hospital · PHUniversity of Colorado Anschutz Medical Campus · USBaylor College of Medicine · USUniversity of the Philippines Manila · PHMED-EL (Austria) · AT

Funding

Genetic and epigenomic determinants of hearing loss in Hispanic populationsR01DC019642 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI SANTOS-CORTEZ, REGIE LYN PASTOR, YANG, IVANA V · 2021 to 2025
$3.4M
NIDCD NIH HHS R01 DC019642
6 · The paper itself

Abstract

Objective: Recent advances in epigenetic studies continue to reveal novel mechanisms of gene regulation and control, however little is known on the role of epigenetics in sensorineural hearing loss (SNHL) in humans. We aimed to investigate the methylation patterns of two regions, one in Methods: We investigated an Results: Using qMSP, both our cases and controls had zero methylation at the targeted Conclusion: Our study showed no changes in methylation at the selected CpG regions in

Indexed as

GJB2hearing lossmethylationqMSPRB1sensorineural

Identifiers

PMID37990697
PMCPMC10662870
OpenAlexW4387079630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.