ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4
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In one paragraph
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 18 citations in OpenAlex.
- Horizontal mitochondrial transfer and mitochondrial transplantation in skin: protection against UVR-induced ROS damage and enhancement of cell proliferation and wound healing.Journal of translational medicine · 2026Article
- Immune Checkpoint Inhibitors in Cancer Patients With Concurrent Active Tuberculosis: A Real-World Study in a High Tuberculosis Burden Region.Open forum infectious diseases · 2026Article
- Host immunosenescence compromisesAging · 2026Article
- Mitochondrial Transfer: From Bench to Bedside.Circulation research · 2026Review
- Host mitochondrial DNA in bacterial pathogenesis: Friend, Foe, or Both?Archives of microbiology · 2026Review
- The Janus face of tissue-resident memory T cells: dual programming in tumor immune surveillance and autoimmune pathology.Frontiers in immunology · 2026Review
- Immunotherapy for tuberculosis: emerging modalities, cross-disciplinary innovations, and roadmaps for drug-resistant disease.Frontiers in immunology · 2026Review
- Mitochondrial transfer as a driver of immune microenvironment remodeling.Frontiers in immunology · 2026Review
- SIRT6-Mediated Regulation of TFAM: A Central Mechanism Connecting Nuclear and Mitochondrial Transcriptional Processes and Mitophagy.International journal of biological sciences · 2026Article
- Mitochondrial transfer in the tumor microenvironment: a dynamic determinant of cancer plasticity, immune dysfunction, and therapeutic opportunity.Frontiers in immunology · 2026Review
- Multiscale Construction, Evaluation, and Application of Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms.EMBO reports · 2025Review
- Mitochondria and lysosomes in T cell immunometabolism.Trends in immunology · 2025Review
- Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges.Journal of hematology & oncology · 2025Review
- Mitochondrial sirtuins, key regulators of aging.Life medicine · 2025Review
- From powerhouse to modulator: regulating immune system responses through intracellular mitochondrial transfer.Cell communication and signaling : CCS · 2025Review
- Mitochondrial Transplantation Promotes Protective Effector and Memory CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Revolutionizing Postdoctoral Training Using the Social Ecological Model: Insights and Experiences from the Propel Scholars.GEN biotechnology · 2024Article
- HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa.Mucosal immunology · 2024Article
- Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments.Circulation research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 4 institutions in 1 country.
Colwyn A HeadleyHost-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.ORCID 0000-0001-6041-7615
Shalini GautamHost-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.ORCID 0000-0002-3739-0247
Angelica Olmo-FontanezPopulation Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Andreu Garcia-VilanovaPopulation Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Varun DwivediHost-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Anwari AkhterPopulation Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Alyssa SchamiPopulation Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Kevin ChiemDisease Intervention & Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Russell AultHost-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Hao ZhangDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, 78249, USA.
Hong CaiDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, 78249, USA.
Alison WhighamHost-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Jennifer DelgadoHost-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Amberlee HicksHost-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Philip S TsaoStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Jonathan GelfondUT-Health San Antonio, Department of Epidemiology & Biostatistics, San Antonio, Texas, 78229, USA.
Luis Martinez-SobridoDisease Intervention & Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Yufeng WangDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, 78249, USA.
Jordi B TorrellesPopulation Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Joanne TurnerHost-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Texas Biomedical Research Institute · USTexas Center for Infectious Disease · USCardiovascular Institute of the South · USThe University of Texas Health Science Center at San Antonio · US
Funding
TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6MSocial stress as a co-morbidity of age-associated tuberculosisP01AG051428 · NIA · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI TORRELLES, JORDI B · 2016 to 2020
$9.9MT32 Training Program in Mechanisms and Innovation in Vascular DiseaseT32HL098049 · NHLBI · STANFORD UNIVERSITY · PI Nicholas James Leeper, Philip S Tsao · 2010 to 2026
$6.3MBD FACSymphonyS10OD028653 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI TURNER, JOANNE · 2020 to 2020
$463kElucidate the adverse impact of mitochondria-induced oxidative stress in molecular and cellular determinants in the aging lung, driving susceptibility to Mycobacterium tuberculosis infectionF99AG079802 · NIA · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI OLMO-FONTANEZ, ANGELICA MILAGROS · 2022 to 2022
$38kNHLBI NIH HHS 1T32HL098049NHLBI NIH HHS T32 HL098049NIA NIH HHS F99 AG079802NIA NIH HHS P01 AG051428NIA NIH HHS P30 AG013319NIH HHS P01AG051428NIH HHS S10 OD028653NIH HHS S10OD028653
Abstract
Mitochondrial dysfunction alters cellular metabolism, increases tissue oxidative stress, and may be principal to the dysregulated signaling and function of CD4
Indexed as
AgingMitochondrial DiseasesAgedAnimalsCD4-Positive T-LymphocytesHumansMiceMitochondriaT-Lymphocytes, Regulatoryadaptive immunityaging immunologyCD4+ T cellsimmunometabolismmitochondrial dysfunction
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.