ArticleBrain and behavior2023
Upregulation of Pin1 contributes to alleviation of cognitive dysfunction in diabetic mice.
Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Brain insulin resistance: a key pathological hub linking metabolic and neuropsychiatric comorbidities.Frontiers in aging neuroscience · 2026Review
- Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery.Science signaling · 2024Review
- Upregulation of Pin1 contributes to alleviation of cognitive dysfunction in diabetic mice.Brain and behavior · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThis study aimed to explore the molecular mechanism underlying the role of Pin1 in cognitive dysfunction in diabetic mice.
methodsUsing a streptozotocin-induced diabetic mouse model, an adeno-associated virus carrying the Pin1 gene was used to upregulate Pin1 expression in the hippocampus of diabetic mice. Animal behavior tests and molecular biology techniques were further used to explore the role of Pin1 in cognitive dysfunction in diabetic mice.
resultsOur study demonstrated that upregulation of Pin1 expression increased the phosphorylation of AKT and insulin receptor substrate 1 downstream signaling molecules of the IR-IGF1R pathway, increased the phosphorylation of GSK-3β, and concomitantly decreased the phosphorylation of Tau in the hippocampus of diabetic mice, thereby improving the ultrastructural pathology of the hippocampus and further alleviating diabetes-related cognitive impairment.
conclusionPin1 can improve cognitive dysfunction in diabetic mice.
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