Evidence map›Paper›PMID 37990347›Full record

ArticleMobile DNA2023

Proceedings of the inaugural Dark Genome Symposium: November 2022.

Jef D Boeke, Kathleen H Burns, Katherine B Chiappinelli, Marie Classon, John M Coffin, Daniel D DeCarvalho, Joseph D Dukes, Benjamin Greenbaum, George Kassiotis, Sarah K Knutson and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mobile DNA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jef D BoekeInstitute for Systems Genetics, NYU Langone Health, New York, NY, 10016, USA.
Kathleen H BurnsDepartment of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Katherine B ChiappinelliDepartment of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA.
Marie ClassonPfizer Centre for Therapeutic Innovation, San Diego, USA.
John M CoffinDepartment of Molecular Biology and Microbiology, Tufts University, Boston, MA, 02111, USA.
Daniel D DeCarvalhoPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Joseph D DukesEnara Bio Limited, Magdalen Centre, 1 Robert Robinson Avenue, The Oxford Science Park, Oxford, OX4 4GA, UK.
Benjamin GreenbaumComputational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
George KassiotisRetroviral Immunology Laboratory, The Francis Crick Institute, London, UK.
Sarah K KnutsonRome Therapeutics, 201 Brookline Avenue, Suite 1001, Boston, MA, USA.
Arnold J LevineSimons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, USA.
Avindra NathSection for Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Sophie PapaEnara Bio Limited, Magdalen Centre, 1 Robert Robinson Avenue, The Oxford Science Park, Oxford, OX4 4GA, UK. sophie.papa@enarabio.com.
Daniel RiosRome Therapeutics, 201 Brookline Avenue, Suite 1001, Boston, MA, USA.
John SedivyCenter on the Biology of Aging, Brown University, Providence, RI, USA.
David T TingDepartment of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Somatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI John M Sedivy · 2016 to 2026
$30.4M
MECHANISMS OF REPLICATIVE SENESCENCE IN CELLSR01AG016694 · NIA · BROWN UNIVERSITY · PI SEDIVY, JOHN M · 1999 to 2024
$5.7M
NIA NIH HHS P01 AG051449NIA NIH HHS R01 AG016694
6 · The paper itself

Abstract

In November 2022 the first Dark Genome Symposium was held in Boston, USA. The meeting was hosted by Rome Therapeutics and Enara Bio, two biotechnology companies working on translating our growing understanding of this vast genetic landscape into therapies for human disease. The spirit and ambition of the meeting was one of shared knowledge, looking to strengthen the network of researchers engaged in the field. The meeting opened with a welcome from Rosana Kapeller and Kevin Pojasek followed by a first session of field defining talks from key academics in the space. A series of panels, bringing together academia and industry views, were then convened covering a wide range of pertinent topics. Finally, Richard Young and David Ting gave their views on the future direction and promise for patient impact inherent in the growing understanding of the Dark Genome.

Identifiers

PMID37990347
PMCPMC10664479

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.