Evidence map›Paper›PMID 37990307›Full record

ReviewBMC ophthalmology2023

Ocular involvement in pediatric Behçet's disease: is it different than in adults? (a short case series and mini review).

Casem Azri, Perrine Dusser, Laura Eid, Emmanuel Barreau, Isabelle Kone-Paut, Charlotte Borocco, Caroline Galeotti, Sami Saad, Marc Labetoulle, Antoine Rousseau

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Uveitis in paediatric Behçet disease: a large multicentric Italian cohort.Therapeutic advances in musculoskeletal disease · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Casem AzriService d'Ophtalmologie, Assistance Publique Hôpitaux de Paris (AP-HP), Université Paris-Saclay. Centre de Référence Pour Les Maladies Rares en Ophtalmologie (OPHTARA), Hôpital Bicêtre, 78, Rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
Perrine DusserPaediatric Rheumatology Department, APHP, Bicêtre Hospital, Le Kremlin-Bicêtre, 94270, France.
Laura EidService d'Ophtalmologie, Assistance Publique Hôpitaux de Paris (AP-HP), Université Paris-Saclay. Centre de Référence Pour Les Maladies Rares en Ophtalmologie (OPHTARA), Hôpital Bicêtre, 78, Rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
Emmanuel BarreauService d'Ophtalmologie, Assistance Publique Hôpitaux de Paris (AP-HP), Université Paris-Saclay. Centre de Référence Pour Les Maladies Rares en Ophtalmologie (OPHTARA), Hôpital Bicêtre, 78, Rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
Isabelle Kone-PautPaediatric Rheumatology Department, APHP, Bicêtre Hospital, Le Kremlin-Bicêtre, 94270, France.
Charlotte BoroccoPaediatric Rheumatology Department, APHP, Bicêtre Hospital, Le Kremlin-Bicêtre, 94270, France.
Caroline GaleottiPaediatric Rheumatology Department, APHP, Bicêtre Hospital, Le Kremlin-Bicêtre, 94270, France.
Sami SaadService d'Ophtalmologie, Centre Hospitalier National Ophtalmologique des 15-20, Paris, France.
Marc LabetoulleService d'Ophtalmologie, Assistance Publique Hôpitaux de Paris (AP-HP), Université Paris-Saclay. Centre de Référence Pour Les Maladies Rares en Ophtalmologie (OPHTARA), Hôpital Bicêtre, 78, Rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
Antoine RousseauService d'Ophtalmologie, Assistance Publique Hôpitaux de Paris (AP-HP), Université Paris-Saclay. Centre de Référence Pour Les Maladies Rares en Ophtalmologie (OPHTARA), Hôpital Bicêtre, 78, Rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France. antoine.rousseau@aphp.fr.
Bicêtre Hospital · FRCentre de Référence des Maladies Autoinflammatoires et des Amyloses · FRCEA Paris-Saclay - Etablissement de Fontenay-aux-roses · FRCentre hospitalier national d'ophtalmologie des Quinze-Vingts · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPediatric Behçet's disease (PBD) is rarer than BD and can be a challenging diagnosis as clinical picture may be incomplete. As in adult patients, sight-threatening ocular manifestations may lead to diagnosis. In this study, we aimed to report a series of cases of PBD with ocular manifestations and provide a review of the literature.

methodsRetrospective case series of PBD patients with ocular manifestations. Demographic, ophthalmological and systemic data at presentation and during follow-up were collected and analyzed.

resultsFour patients, aged 13.0 ± 2.9 years (9-16) were included. Posterior uveitis with retinal vasculitis, papillitis and macular edema was present in all patients, with associated anterior uveitis in 2 cases. Other features included occlusive vasculitis (2/4) and necrotizing retinitis (2/4). All patients were improved by systemic treatments except one patient with severe bilateral optic neuropathy. Ocular manifestations were the presenting symptoms in 3/4 cases.

conclusionOcular manifestations and systemic associations of PBD are comparable to those encountered in adult patients. The lack of complains in pediatric patients may lead to a longer diagnosis delay, especially in unilateral uveitis. Aggressive and long-term treatment is mandatory to prevent vision loss and recurrences.

Indexed as

Behcet SyndromeUveitisAdolescentAdultChildHumansRetrospective StudiesVision DisordersVision, OcularBiotherapiesPediatric Behçet diseaseUveitisVasculitis

Identifiers

PMID37990307
PMCPMC10664259
OpenAlexW4388862292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.