Evidence map›Paper›PMID 37990229›Full record

ArticleVirology journal2023

Systemic perturbations in amino acids/amino acid derivatives and tryptophan pathway metabolites associated with murine influenza A virus infection.

Huda A M Al-Shalan, Lu Zhou, Zhifan Dong, Penghao Wang, Philip K Nicholls, Berin Boughton, Philip A Stumbles, Wayne K Greene, Bin Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts.Metabolomics : Official journal of the Metabolomic Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Huda A M Al-ShalanSchool of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA, Australia.
Lu ZhouGraduate School, Hebei Medical University, Shijiazhuang, Hebei, China.
Zhifan DongGraduate School, Hebei Medical University, Shijiazhuang, Hebei, China.
Penghao WangSchool of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA, Australia.
Philip K NichollsSchool of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA, Australia.
Berin BoughtonAustralian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Murdoch, WA, Australia.
Philip A StumblesSchool of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA, Australia.
Wayne K GreeneSchool of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA, Australia.
Bin MaSchool of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA, Australia. B.Ma@murdoch.edu.au.
Murdoch University · AUHebei Medical University · CNAvenir Health · US

Funding

Ministry of Higher Education & Scientific Research of Iraq 4394
6 · The paper itself

Abstract

backgroundInfluenza A virus (IAV) is the only influenza virus causing flu pandemics (i.e., global epidemics of flu disease). Influenza (the flu) is a highly contagious disease that can be deadly, especially in high-risk groups. Worldwide, these annual epidemics are estimated to result in about 3 to 5 million cases of severe illness and in about 290,000 to 650,000 respiratory deaths. We intend to reveal the effect of IAV infection on the host's metabolism, immune response, and neurotoxicity by using a mouse IAV infection model.

methods51 metabolites of murine blood plasma (33 amino acids/amino acid derivatives (AADs) and 18 metabolites of the tryptophan pathway) were analyzed by using Ultra-High-Performance Liquid Chromatography-Mass Spectrometry with Electrospray Ionization at the acute (7 days post-infection (dpi)), resolution (14 dpi), and recovery (21 dpi) stages of the virus infection in comparison with controls.

resultsAmong the 33 biogenic amino acids/AADs, the levels of five amino acids/AADs (1-methylhistidine, 5-oxoproline, α-aminobutyric acid, glutamine, and taurine) increased by 7 dpi, whereas the levels of ten amino acids/AADs (4-hydroxyproline, alanine, arginine, asparagine, cysteine, citrulline, glycine, methionine, proline, and tyrosine) decreased. By 14 dpi, the levels of one AAD (3-methylhistidine) increased, whereas the levels of five amino acids/AADs (α-aminobutyric acid, aminoadipic acid, methionine, threonine, valine) decreased. Among the 18 metabolites from the tryptophan pathway, the levels of kynurenine, quinolinic acid, hydroxykynurenine increased by 7 dpi, whereas the levels of indole-3-acetic acid and nicotinamide riboside decreased.

conclusionsOur data may facilitate understanding the molecular mechanisms of host responses to IAV infection and provide a basis for discovering potential new mechanistic, diagnostic, and prognostic biomarkers and therapeutic targets for IAV infection.

Indexed as

Influenza A virusInfluenza, HumanAmino AcidsAminobutyratesAnimalsHumansMethionineMiceTryptophanalpha-aminobutyric acidAmino AcidsAminobutyratesMethionineTryptophanAmino acidsImmunometabolismInfectionInfluenzaInfluenza A virusMetabolitesNeurotoxicityTryptophan pathway

Identifiers

PMID37990229
PMCPMC10664681
OpenAlexW4388855774

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.