Evidence map›Paper›PMID 37990202›Full record

ArticleBMC psychiatry2023

ARFID Genes and Environment (ARFID-GEN): study protocol.

Cynthia M Bulik, Nadia Micali, Casey M MacDermod, Baiyu Qi, Melissa A Munn-Chernoff, Laura M Thornton, Jennifer White, Lisa Dinkler, Emily M Pisetsky, Jessica Johnson and 8 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05605067 (Genetic Architecture of Avoidant/Restrictive Food Intake Disorder), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05605067 completednot on this map

Genetic Architecture of Avoidant/Restrictive Food Intake Disorder

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2023 to 2024Enrolled5,076ConditionsARFID, Eating Disorders, Eating Disorders in Children, Eating, Picky
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Associations Between Avoidant/Restrictive Food Intake Disorder Dimensions and Obsessive-Compulsive Symptomatology.European eating disorders review : the journal of the Eating Disorders Association · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 5 countries.

Cynthia M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. cynthia_bulik@med.unc.edu.
Nadia MicaliCenter for Eating and Feeding Disorders Research, Psychiatric Center Ballerup, Mental Health Services of the Capital Region of Denmark, Ballerup, Denmark.
Casey M MacDermodDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Baiyu QiDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA.
Melissa A Munn-ChernoffDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Laura M ThorntonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Jennifer WhiteDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Lisa DinklerDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden.
Emily M PisetskyDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Jessica JohnsonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Katelin R DevineDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Shelby N OrtizDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Ava E SilvermanDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Natasha BertholdDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Alexis DumainDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Jerry GuintivanoDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Matthew HalvorsenDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
James J CrowleyDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
University of North Carolina at Chapel Hill · USKarolinska Institutet · SEPerron Institute for Neurological and Translational Science · AUSankt Hans Hospital · DKSmith College · USTexas Tech University · US

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
OCD: Novel Comparative Genomic Approaches to Identify Disease and Treatment MechanismsR01MH110427 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CROWLEY, JAMES JOSEPH · 2016 to 2021
$3.0M
Genetic Architecture of Avoidant/Restrictive Food Intake DisorderR56MH129437 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, MICALI, NADIA · 2022 to 2023
$1.5M
NCATS NIH HHS UL1 TR001111NIMH NIH HHS R01 MH110427NIMH NIH HHS R56 MH129437NIMH NIH HHS R56MH129437
6 · The paper itself

Abstract

backgroundThe Avoidant Restrictive Food Intake Disorder - Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults.

methodsA total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18 +) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted. DISCUSSION: ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver "actionable" findings that can be transformed into clinically meaningful insights.

trial registrationARFID-GEN is a registered clinical trial: clinicaltrials.gov NCT05605067.

Indexed as

Avoidant Restrictive Food Intake DisorderFeeding and Eating DisordersAdultChildClinical Trials as TopicGenome-Wide Association StudyHumansMotivationRetrospective StudiesAvoidant restrictive food intake disorderEating disordersGenome-wide associationPicky eatingPsychiatric geneticsPsychiatric genomics consortiumSelective eatingSocial media

Identifiers

PMID37990202
PMCPMC10664384
OpenAlexW4388866072

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.