Evidence map›Paper›PMID 37990147›Full record

ArticleBMC genomics2023

Genome-wide identification and characteristic analysis of ETS gene family in blood clam Tegillarca granosa.

Hongyu Jin, Weiwei Zhang, Hongxing Liu, Yongbo Bao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hongyu JinSchool of Marine Sciences, Ningbo University, Ningbo, 315000, China.
Weiwei ZhangSchool of Marine Sciences, Ningbo University, Ningbo, 315000, China.
Hongxing LiuZhejiang Key Laboratory of Aquatic Germplasm Resources, College of Biological & Environmental Sciences, Zhejiang Wanli University, Zhejiang, 315100, China. liuhongxing@zwu.edu.cn.
Yongbo BaoZhejiang Key Laboratory of Aquatic Germplasm Resources, College of Biological & Environmental Sciences, Zhejiang Wanli University, Zhejiang, 315100, China. baoyongbo@zwu.edu.cn.
Zhejiang Wanli University · CNNingbo University · CN

Funding

Key Natural Science Foundation of Zhejiang LZ20C190001National Science Foundation of China 32273123Ningbo Public Benefit Research Key Project 2021S014Science Foundation of Zhejiang LQ23C190007Zhejiang Major Program of Science and Technology 2021C02069-7
6 · The paper itself

Abstract

backgroundETS transcription factors, known as the E26 transformation-specific factors, assume a critical role in the regulation of various vital biological processes in animals, including cell differentiation, the cell cycle, and cell apoptosis. However, their characterization in mollusks is currently lacking.

resultsThe current study focused on a comprehensive analysis of the ETS genes in blood clam Tegillarca granosa and other mollusk genomes. Our phylogenetic analysis revealed the absence of the SPI and ETV subfamilies in mollusks compared to humans. Additionally, several ETS genes in mollusks were found to lack the PNT domain, potentially resulting in a diminished ability of ETS proteins to bind target genes. Interestingly, the bivalve ETS1 genes exhibited significantly high expression levels during the multicellular proliferation stage and in gill tissues. Furthermore, qRT-PCR results showed that Tg-ETS-14 (ETS1) is upregulated in the high total hemocyte counts (THC) population of T. granosa, suggesting it plays a significant role in stimulating hemocyte proliferation.

conclusionOur study significantly contributes to the comprehension of the evolutionary aspects concerning the ETS gene family, while also providing valuable insights into its role in fostering hemocyte proliferation across mollusks.

Indexed as

ArcidaeBivalviaAnimalsGenomeHumansPhylogenyProto-Oncogene Proteins c-etsProto-Oncogene Proteins c-etsETSExpression profilingMollusksPhylogenetic analysisTotal hemocyte counts

Identifiers

PMID37990147
PMCPMC10664356
OpenAlexW4388853026

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.