Evidence map›Paper›PMID 37990129›Full record

ArticleScientific reports2023

Hepatocyte integrity depends on c-Jun-controlled proliferation in Schistosoma mansoni infected mice.

Lukas Härle, Verena von Bülow, Lukas Knedla, Frederik Stettler, Heike Müller, Daniel Zahner, Simone Haeberlein, Anita Windhorst, Annette Tschuschner, Monika Burg-Roderfeld and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Implications of host sex on liver metabolism duringFrontiers in cellular and infection microbiology · 2026
    Review
  2. Pharmacological Inhibition of c-Jun N-Terminal Kinase Activity Exacerbates Liver Damage in Schistosoma mansoni Infected Mice.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lukas Härle *Department of Gastroenterology, Justus Liebig University Giessen, Gaffkystr. 11c, 35392, Giessen, Germany.
Verena von Bülow *Department of Gastroenterology, Justus Liebig University Giessen, Gaffkystr. 11c, 35392, Giessen, Germany.
Lukas KnedlaDepartment of Gastroenterology, Justus Liebig University Giessen, Gaffkystr. 11c, 35392, Giessen, Germany.
Frederik StettlerDepartment of Gastroenterology, Justus Liebig University Giessen, Gaffkystr. 11c, 35392, Giessen, Germany.
Heike MüllerDepartment of Gastroenterology, Justus Liebig University Giessen, Gaffkystr. 11c, 35392, Giessen, Germany.
Daniel ZahnerCentral Laboratory Animal Facility, Justus Liebig University Giessen, 35392, Giessen, Germany.
Simone HaeberleinInstitute of Parasitology, BFS, Justus Liebig University Giessen, 35392, Giessen, Germany.
Anita WindhorstInstitute of Medical Informatics, Justus Liebig University Giessen, 35392, Giessen, Germany.
Annette TschuschnerDepartment of Gastroenterology, Justus Liebig University Giessen, Gaffkystr. 11c, 35392, Giessen, Germany.
Monika Burg-RoderfeldHochschulen Fresenius GmbH, University of Applied Sciences, 65510, Idstein, Germany.
Kernt KöhlerInstitute of Veterinary Pathology, Justus Liebig University Giessen, Giessen, Germany.
Christoph G GreveldingInstitute of Parasitology, BFS, Justus Liebig University Giessen, 35392, Giessen, Germany.
Elke Roeb *Department of Gastroenterology, Justus Liebig University Giessen, Gaffkystr. 11c, 35392, Giessen, Germany.
Martin Roderfeld *Department of Gastroenterology, Justus Liebig University Giessen, Gaffkystr. 11c, 35392, Giessen, Germany. martin.roderfeld@innere.med.uni-giessen.de.ORCID 0000-0002-3232-1277
Justus-Liebig-Universität Gießen · DEHochschule Fresenius · DE

Funding

Wellcome TrustWellcome Trust 107475/Z/15/Z
6 · The paper itself

Abstract

Schistosomiasis is a parasitic disease affecting more than 250 million people worldwide. The transcription factor c-Jun, which is induced in S. mansoni infection-associated liver disease, can promote hepatocyte survival but can also trigger hepatocellular carcinogenesis. We aimed to analyze the hepatic role of c-Jun following S. mansoni infection. We adopted a hepatocyte-specific c-Jun knockout mouse model (Alb-Cre/c-Jun loxP) and analyzed liver tissue and serum samples by quantitative real-time PCR array, western blotting, immunohistochemistry, hydroxyproline quantification, and functional analyses. Hepatocyte-specific c-Jun knockout (c-Jun

Indexed as

Schistosoma mansoniSchistosomiasis mansoniAnimalsCell ProliferationCyclin D1HepatocytesHumansLiverMiceCyclin D1

Identifiers

PMID37990129
PMCPMC10663609
OpenAlexW4388854178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.