Evidence map›Paper›PMID 37990119›Full record

ArticleScientific reports2023

Functional genome analysis and anti-Helicobacter pylori activity of a novel bacteriocinogenic Lactococcus sp. NH2-7C from Thai fermented pork (Nham).

Engkarat Kingkaew, Weerapong Woraprayote, Auttaporn Booncharoen, Kanidta Niwasabutra, Thitiphorn Janyaphisan, Ratha-Korn Vilaichone, Yoshio Yamaoka, Wonnop Visessanguan, Somboon Tanasupawat

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Evaluating the safety and efficacy ofFrontiers in microbiology · 2025
    Article
  3. The role of probiotic supplementation in reducingFrontiers in pharmacology · 2025
    Article
  4. Review
  5. Genomic Assessment of Potential ProbioticTropical life sciences research · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Engkarat KingkaewDepartment of Biology, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.
Weerapong WoraprayoteNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand.
Auttaporn BooncharoenNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand.
Kanidta NiwasabutraThailand Institute of Scientific and Technological Research (TISTR) Biodiversity Research Centre, Pathum Thani, 12120, Thailand.
Thitiphorn JanyaphisanNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand.
Ratha-Korn VilaichoneGI Unit, Department of Medicine, and Center of Excellence in Digestive Diseases, Thammasat University, Thailand Science Research and Innovation Fundamental Fund, Bualuang ASEAN Chair Professorship at Thammasat University, Pathum Thani, 12120, Thailand.
Yoshio YamaokaDepartment of Environmental and Preventive Medicine, Faculty of Medicine Oita University, Yufu, Oita, Japan.
Wonnop VisessanguanNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand. wonnop@biotec.or.th.
Somboon TanasupawatDepartment of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand. Somboon.T@chula.ac.th.
Chulalongkorn University · THNational Center for Genetic Engineering and Biotechnology · THNational Science and Technology Development Agency · THOita University · JPThailand Institute of Scientific and Technological Research · THThammasat University · TH

Funding

Thailand Science Research and Innovation Fund Chulalongkorn University (HEA663300001). HEA663300001
6 · The paper itself

Abstract

Helicobacter pylori, linked to gastric diseases, is targeted for probiotic treatment through bacteriocin production. Bacteriocins have gained recognition for their non-toxic effects on host cells and their ability to combat a wide range of pathogens. This study aimed to taxonomically characterize and evaluate the safety and probiotic properties of the novel species of Lactococcus sp. NH2-7C isolated from fermented pork, as well as its bacteriocin NH2-7C, both in vitro and in silico. Comparative genotypic analysis revealed an average nucleotide identity of 94.96%, an average amino acid identity of 94.29%, and a digital DNA-DNA hybridization value of 63.80% when compared to Lactococcus lactis subsp. lactis JCM 5805

Indexed as

BacteriocinsHelicobacter pyloriLactococcus lactisPork MeatAnimalsCaco-2 CellsDNASwineBacteriocinsDNA

Identifiers

PMID37990119
PMCPMC10663479
OpenAlexW4388856470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.