Evidence map›Paper›PMID 37990057›Full record

ArticleScientific reports2023

Additive manufacturing of poly (lactic acid)/hydroxyapatite/carbon nanotubes biocomposites for fibroblast cell proliferation.

Francilene da Luz Belo, Esleane Vilela Vasconcelos, Miriane Alexandrino Pinheiro, Damares da Cruz Barbosa Nascimento, Marcele Fonseca Passos, Alisson Clay Rios da Silva, Marcos Allan Leite Dos Reis, Sérgio Neves Monteiro, Rebecca Thereza Silva Santa Brígida, Ana Paula Drummond Rodrigues and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Materials advances in GTR membrane: A comprehensive review.Journal of Taibah University Medical Sciences · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Francilene da Luz BeloEngineering of Natural Resources of the Amazon Program, Federal University of Pará-UFPA, Belém, Brazil.
Esleane Vilela VasconcelosEngineering of Natural Resources of the Amazon Program, Federal University of Pará-UFPA, Belém, Brazil.
Miriane Alexandrino PinheiroEngineering of Natural Resources of the Amazon Program, Federal University of Pará-UFPA, Belém, Brazil.
Damares da Cruz Barbosa NascimentoMaterials Science and Engineering Program, Federal University of Pará-UFPA, Belém, Brazil.
Marcele Fonseca PassosMaterials Science and Engineering Program, Federal University of Pará-UFPA, Belém, Brazil.
Alisson Clay Rios da SilvaMaterials Science and Engineering Program, Federal University of Pará-UFPA, Belém, Brazil.
Marcos Allan Leite Dos ReisEngineering of Natural Resources of the Amazon Program, Federal University of Pará-UFPA, Belém, Brazil.
Sérgio Neves MonteiroMaterials Science Program, Military Institute of Engineering-IME, Rio de Janeiro, Brazil.
Rebecca Thereza Silva Santa BrígidaElectron Microscopy Laboratory, Evandro Chagas Institute-IEC, Belém, Brazil.
Ana Paula Drummond RodriguesElectron Microscopy Laboratory, Evandro Chagas Institute-IEC, Belém, Brazil.
Verônica Scarpini CandidoEngineering of Natural Resources of the Amazon Program, Federal University of Pará-UFPA, Belém, Brazil. scarpini@ufpa.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone tissue is one of the most important in the human body. In this study, scaffolds of poly (lactic acid) PLA reinforced with hydroxyapatite (HA) and carbon nanotubes (CNT) were manufactured, evaluating their mechanical and biological properties. HA was synthesized by wet method and characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The scaffolds were produced using additive manufacturing and characterized by optical microscopy, SEM, thermogravimetric analysis (TGA), Raman spectroscopy and biological tests. The SEM results showed that the PLA surface was affected by the incorporation of CNT. TG showed that the incorporation of HA into the polymer matrix compromised the thermal stability of PLA. On the other hand, the incorporation of CNT to the polymer and the impregnation with HA on the surface by thermal effect increased the stability of PLA/CNT scaffolds. Raman spectra indicated that HA impregnation on the surface did not modify the polymer or the ceramic. In the compression tests, PLA and PLA/CNT scaffolds displayed the best compressive strength. In the biological tests, more than 85% of the cells remained viable after 48 h of incubation with all tested scaffolds and groups with CNT in the composition disclosing the best results.

Indexed as

DurapatiteNanotubes, CarbonCell ProliferationFibroblastsHumansLactic AcidPolyestersPolymersSpectroscopy, Fourier Transform InfraredTissue ScaffoldsDurapatiteLactic AcidNanotubes, CarbonPolyestersPolymers

Identifiers

PMID37990057
PMCPMC10663481

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.