Evidence map›Paper›PMID 37990055›Full record

ArticleScientific reports2023

AePUb promoter length modulates gene expression in Aedes aegypti.

Michelle A E Anderson, Philip T Leftwich, Ray Wilson, Leonela Z Carabajal Paladino, Sanjay Basu, Sara Rooney, Zach N Adelman, Luke Alphey

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Michelle A E AndersonArthropod Genetics, The Pirbright Institute, Ash Road, Pirbright, GU24 0HN, UK. michelle.anderson@york.ac.uk.
Philip T LeftwichArthropod Genetics, The Pirbright Institute, Ash Road, Pirbright, GU24 0HN, UK.
Ray WilsonArthropod Genetics, The Pirbright Institute, Ash Road, Pirbright, GU24 0HN, UK.
Leonela Z Carabajal PaladinoArthropod Genetics, The Pirbright Institute, Ash Road, Pirbright, GU24 0HN, UK.
Sanjay BasuArthropod Genetics, The Pirbright Institute, Ash Road, Pirbright, GU24 0HN, UK.
Sara RooneyArthropod Genetics, The Pirbright Institute, Ash Road, Pirbright, GU24 0HN, UK.
Zach N AdelmanDepartment of Entomology, Texas A&M University, College Station, TX, USA.
Luke AlpheyArthropod Genetics, The Pirbright Institute, Ash Road, Pirbright, GU24 0HN, UK. luke.alphey@york.ac.uk.
The Pirbright Institute · GBOxitec (United Kingdom) · GBTexas A&M University · USUniversity of York · GB

Funding

Translational Research Core - Health Engagement & Action Translational (HEAT)P30DK092924 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI Alyce Sophia Adams, HILARY Kessler SELIGMAN · 2011 to 2026
$9.2M
Biotechnology and Biological Sciences Research Council BBS/E/I/00007033Biotechnology and Biological Sciences Research Council BBS/E/I/00007038Biotechnology and Biological Sciences Research Council BBS/E/I/00007039NIDDK NIH HHS P30 DK092924Wellcome TrustWellcome Trust 110117/Z/15/Z
6 · The paper itself

Abstract

Molecular tools for modulating transgene expression in Aedes aegypti are few. Here we demonstrate that adjustments to the AePUb promoter length can alter expression levels of two reporter proteins in Ae. aegypti cell culture and in mosquitoes. This provides a simple means for increasing or decreasing expression of a gene of interest and easy translation from cells to whole insects.

Indexed as

AedesAnimalsGene ExpressionPromoter Regions, GeneticTransgenes

Identifiers

PMID37990055
PMCPMC10663553
OpenAlexW4388865563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.