Evidence map›Paper›PMID 37990024›Full record

ArticleNPJ vaccines2023

BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer.

Rajesh M Valanparambil, Lilin Lai, Margaret A Johns, Meredith Davis-Gardner, Susanne L Linderman, Tarrant Oliver McPherson, Andres Chang, Akil Akhtar, Estefany L Bocangel Gamarra, Hayley Matia and 13 more

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Rajesh M ValanparambilEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Lilin LaiEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Margaret A JohnsWinship Cancer Institute of Emory University, Atlanta, GA, USA.
Meredith Davis-GardnerEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Susanne L LindermanEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Tarrant Oliver McPhersonDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, USA.
Andres ChangEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-6679-9060
Akil AkhtarEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-9069-6827
Estefany L Bocangel GamarraEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Hayley MatiaWinship Cancer Institute of Emory University, Atlanta, GA, USA.
Ashley A McCook-VealDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, USA.ORCID http://orcid.org/0000-0001-5368-4977
Jeffrey SwitchenkoDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, USA.
Tahseen H NastiEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Felicia GreenWinship Cancer Institute of Emory University, Atlanta, GA, USA.
Manpreet SainiEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Andreas WielandEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Benjamin A PinskyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Daniel SolisDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Madhav V DhodapkarWinship Cancer Institute of Emory University, Atlanta, GA, USA.
Jennifer CarlisleWinship Cancer Institute of Emory University, Atlanta, GA, USA.
Suresh Ramalingam *Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Rafi Ahmed *Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Mehul S Suthar *Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA. mehul.s.suthar@emory.edu.
Emory University · USOregon National Primate Research Center · USStanford University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00017 · NIAID · EMORY UNIVERSITY · PI LOWEN, ANICE · 2021 to 2025
$27.3M
Project-004U54CA260563 · NCI · EMORY UNIVERSITY · PI DHODAPKAR, MADHAV V, SANZ, IGNACIO E. · 2020 to 2024
$10.2M
Project 3: Targeting Bax signaling to overcome treatment resistance in NSCLCP50CA217691 · NCI · EMORY UNIVERSITY · PI DENG, XINGMING · 2019 to 2024
$10.1M
HARNESSING HOST RESPONSE TO PREVENT MYELOMAR35CA197603 · NCI · YALE UNIVERSITY · PI DHODAPKAR, MADHAV V · 2016 to 2022
$5.8M
NCI NIH HHS P30 CA138292NCI NIH HHS P50 CA217691NCI NIH HHS R35 CA197603NCI NIH HHS U54 CA260563NIAID NIH HHS 75N93021C00017NIAID NIH HHS HHSN272201400004CNIAID NIH HHS U19 AI057266NIH HHS P51 OD011132
6 · The paper itself

Abstract

This study reports that most patients with NSCLC had a significant increase in the nAb response to the currently circulating Omicron variants after bivalent booster vaccination and had Ab titers comparable to healthy participants. Interestingly, though the durability of the nAb response persisted in most of the healthy participants, patients with NSCLC had significantly reduced nAb titers after 4-6 months of vaccination. Our data highlight the importance of COVID-19 bivalent booster vaccination as the standard of care for patients with NSCLC given the evolution of new variants of concern.

Identifiers

PMID37990024
PMCPMC10663480
OpenAlexW4388850958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.