Evidence map›Paper›PMID 37989980›Full record

ReviewMolecular neurobiology2024

Neuroimaging Genomics a Predictor of Major Depressive Disorder (MDD).

Manav Jindal, Aakash Chhetri, Abhilash Ludhiadch, Paramdeep Singh, Sameer Peer, Jawahar Singh, Rahatdeep Singh Brar, Anjana Munshi

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Manav JindalDepartment of Radiodiagnosis, All India Institute of Medical Sciences, Bathinda, India.
Aakash ChhetriDepartment of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151401, India.
Abhilash LudhiadchDepartment of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151401, India.
Paramdeep SinghDepartment of Radiodiagnosis, All India Institute of Medical Sciences, Bathinda, India.
Sameer PeerDepartment of Radiodiagnosis, All India Institute of Medical Sciences, Bathinda, India.
Jawahar SinghDepartment of Psychiatry, All India Institute of Medical Sciences, Bathinda, India.
Rahatdeep Singh BrarDepartment of Diagnostic and Interventional Radiology, Homi Bhabha Cancer Hospital & Research Center, Mohali, India.
Anjana MunshiDepartment of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151401, India. anjana.munshi@cup.edu.in.ORCID http://orcid.org/0000-0003-4033-9124
All India Institute of Medical Sciences · INCentral University of Punjab · INBhabha Hospital · IN

Funding

Science and Engineering Research (SERB), Department of Science and Technology (DST) , India SRG/2022/001306
6 · The paper itself

Abstract

Depression is a complex psychiatric disorder influenced by various genetic and environmental factors. Strong evidence has established the contribution of genetic factors in depression through twin studies and the heritability rate for depression has been reported to be 37%. Genetic studies have identified genetic variations associated with an increased risk of developing depression. Imaging genetics is an integrated approach where imaging measures are combined with genetic information to explore how specific genetic variants contribute to brain abnormalities. Neuroimaging studies allow us to examine both structural and functional abnormalities in individuals with depression. This review has been designed to study the correlation of the significant genetic variants with different regions of neural activity, connectivity, and structural alteration in the brain as detected by imaging techniques to understand the scope of biomarkers in depression. This might help in developing novel therapeutic interventions targeting specific genetic pathways or brain circuits and the underlying pathophysiology of depression based on this integrated approach can be established at length.

Indexed as

GenomicsMajor Depressive DisorderNeuroimagingBrainHumansDepressionFunctional magnetic resonance imagingGenetic polymorphismMajor depressive disorderNeuroimaging

Identifiers

PMID37989980
OpenAlexW4388880377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.