Evidence map›Paper›PMID 37989919›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2023

Maternal exposure to polystyrene nanoplastics alters fetal brain metabolism in mice.

Grace V Mercer, Nikita E Harvey, Katherine L Steeves, Céline M Schneider, John G Sled, Christopher K Macgowan, Ahmet A Baschat, John C Kingdom, André J Simpson, Myrna J Simpson and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 38 citations in OpenAlex.

  1. Recent Trends in Metabolomics by NMR Spectroscopy.Angewandte Chemie (International ed. in English) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Grace V MercerDepartment of Chemistry, Memorial University of Newfoundland, Arctic Avenue St. John's, St. John's, Newfoundland, NL, A1C 5S7, Canada.
Nikita E HarveyDepartment of Chemistry, Memorial University of Newfoundland, Arctic Avenue St. John's, St. John's, Newfoundland, NL, A1C 5S7, Canada.
Katherine L SteevesDepartment of Chemistry, Memorial University of Newfoundland, Arctic Avenue St. John's, St. John's, Newfoundland, NL, A1C 5S7, Canada.
Céline M SchneiderDepartment of Chemistry, Memorial University of Newfoundland, Arctic Avenue St. John's, St. John's, Newfoundland, NL, A1C 5S7, Canada.
John G SledMouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada.
Christopher K MacgowanTranslational Medicine, Hospital for Sick Children, Toronto, ON, Canada.
Ahmet A BaschatDepartment of Gynecology & Obstetrics, Johns Hopkins Center for Fetal Therapy, Johns Hopkins University, Baltimore, MD, USA.
John C KingdomDepartment of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada.
André J SimpsonEnvironmental NMR Centre, Department of Physical and Environmental Sciences, University of Toronto, Toronto, ON, Canada.
Myrna J SimpsonEnvironmental NMR Centre, Department of Physical and Environmental Sciences, University of Toronto, Toronto, ON, Canada.
Karl J JobstDepartment of Chemistry, Memorial University of Newfoundland, Arctic Avenue St. John's, St. John's, Newfoundland, NL, A1C 5S7, Canada.
Lindsay S CahillDepartment of Chemistry, Memorial University of Newfoundland, Arctic Avenue St. John's, St. John's, Newfoundland, NL, A1C 5S7, Canada. lcahill@mun.ca.
Memorial University of Newfoundland · CAUniversity of Toronto · CAHospital for Sick Children · CAJohns Hopkins Center for Communication Programs · USMount Sinai Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPlastics used in everyday materials accumulate as waste in the environment and degrade over time. The impacts of the resulting particulate micro- and nanoplastics on human health remain largely unknown. In pregnant mice, we recently demonstrated that exposure to nanoplastics throughout gestation and during lactation resulted in changes in brain structure detected on MRI. One possible explanation for this abnormal postnatal brain development is altered fetal brain metabolism.

objectivesTo determine the effect of maternal exposure to nanoplastics on fetal brain metabolism.

methodsHealthy pregnant CD-1 mice were exposed to 50 nm polystyrene nanoplastics at a concentration of 10

resultsThe relative concentrations of gamma-aminobutyric acid (GABA), creatine and glucose were found to decrease by 40%, 21% and 30% respectively following maternal nanoplastic exposure when compared to the controls (p < 0.05). The change in relative concentration of asparagine with nanoplastic exposure was dependent on fetal sex (p < 0.005).

conclusionMaternal exposure to polystyrene nanoplastics caused abnormal fetal brain metabolism in mice. The present study demonstrates the potential impacts of nanoplastic exposure during fetal development and motivates further studies to evaluate the risk to human pregnancies.

Indexed as

MicroplasticsPolystyrenesAnimalsBrainFemaleHumansMaternal ExposureMetabolomicsMicePregnancyMicroplasticsPolystyrenes1H magic angle spinning nuclear magnetic resonanceFetal brainMetabolomicsMouseNanoplasticsPregnancy

Identifiers

PMID37989919
OpenAlexW4388867523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.