Evidence map›Paper›PMID 37989829›Full record

ReviewDiabetes therapy : research, treatment and education of diabetes and related disorders2024

Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain: A Systematic Literature Review.

Antonio Pérez, Jennifer Redondo-Antón, Irene Romera, Luís Lizán, Miriam Rubio-de Santos, Silvia Díaz-Cerezo, Domingo Orozco-Beltrán

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Antonio PérezServicio de Endocrinología y Nutrición, Hospital de la Santa Creu i Sant Pau, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain.
Jennifer Redondo-AntónEli Lilly and Company, Avda. de la Industria 30, Alcobendas, 28108, Madrid, Spain. redondo_jennifer@lilly.com.ORCID http://orcid.org/0000-0003-2661-5866
Irene RomeraEli Lilly and Company, Avda. de la Industria 30, Alcobendas, 28108, Madrid, Spain.
Luís LizánOutcomes'10, S.L., Castellón de la Plana, Spain.
Miriam Rubio-de SantosEli Lilly and Company, Avda. de la Industria 30, Alcobendas, 28108, Madrid, Spain.
Silvia Díaz-CerezoEli Lilly and Company, Avda. de la Industria 30, Alcobendas, 28108, Madrid, Spain.
Domingo Orozco-BeltránUniversidad Miguel Hernández, Elche, Alicante, Spain.
Eli Lilly (Spain) · ESHospital de Sant Pau · ESUniversitat de Miguel Hernández d'Elx · ESUniversitat Jaume I · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPoor metabolic control and excess body weight are frequently present in people with type 2 diabetes (PwT2D).

methodsA systematic literature review was conducted to identify observational studies reporting clinical, economic, and health-related quality of life (HRQoL) outcomes associated with poor metabolic (according to HbA1c, blood pressure [BP] and low density lipoprotein cholesterol [LDL-C] levels) and/or weight control (defined by a body mass index [BMI] ≥ 30 kg/m

resultsNine observational studies were included in the analysis. Poor glycemic control (HbA1c ≥ 7%) was associated with cardiovascular disease (CVD), increased requirements for antidiabetic medications, higher and more frequent weight gain, a greater probability of hypoglycemia and dyslipidemia, and worse health-related quality of life (HRQoL). Uncontrolled BP in PwT2D was related with the presence of CVD, worse metabolic control, and higher BMI and abdominal perimeter values. Poor LDL-C control or dyslipidemia was associated with CVD, hypoglycemia, and elevated HbA1c and triglycerides levels. The presence of a BMI ≥ 30 kg/m

conclusionGathered evidence supports the high clinical, economic and HRQoL burden of poor metabolic and/or weight control in PwT2D in Spain and reinforces the importance of prioritizing its control to reduce the associated burden, at both the individual and healthcare system levels.

Indexed as

Burden of illnessHbA1cObesityType 2 diabetes mellitus

Identifiers

PMID37989829
PMCPMC10838877
OpenAlexW4388910730

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.