Evidence map›Paper›PMID 37989744›Full record

ReviewSignal transduction and targeted therapy2023

γδ T cells: origin and fate, subsets, diseases and immunotherapy.

Yi Hu, Qinglin Hu, Yongsheng Li, Ligong Lu, Zheng Xiang, Zhinan Yin, Dieter Kabelitz, Yangzhe Wu

Abstract readReview
In one paragraph

Review in Signal transduction and targeted therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 264 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

264 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Programmed cell death in human respiratory syncytial virus infection.Frontiers in cellular and infection microbiology · 2025
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Enrichment of CD4iScience · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. γδ T cells and cancer.The Journal of clinical investigation · 2026
    Review
  18. The long-lived immune system of centenarians.Nature reviews. Immunology · 2026
    Review
  19. γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  20. Article

204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yi Hu *Microbiology and Immunology Department, School of Medicine, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, 510632, China.
Qinglin Hu *Microbiology and Immunology Department, School of Medicine, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, 510632, China.
Yongsheng LiDepartment of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, 400030, China.ORCID 0000-0003-2175-9449
Ligong LuGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, 519000, China.ORCID 0000-0003-1405-0052
Zheng XiangMicrobiology and Immunology Department, School of Medicine, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, 510632, China.
Zhinan YinBiomedical Translational Research Institute, Jinan University, Guangzhou, Guangdong, 510632, China. tzhinan@jnu.edu.cn.ORCID 0000-0001-6524-8777
Dieter KabelitzInstitute of Immunology, Christian-Albrechts-University Kiel, Kiel, Germany. dietrich.kabelitz@uksh.de.ORCID 0000-0002-4160-7103
Yangzhe WuGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, 519000, China. tyzwu@jnu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32030036National Natural Science Foundation of China (National Science Foundation of China) 32270950National Natural Science Foundation of China (National Science Foundation of China) 82002787
6 · The paper itself

Abstract

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential of immune renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering the use of allogeneic Vδ2

Indexed as

NeoplasmsReceptors, Antigen, T-Cell, gamma-deltaCytokinesHumansImmunotherapyT-Lymphocyte SubsetsTumor MicroenvironmentCytokinesReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID37989744
PMCPMC10663641

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.