Evidence map›Paper›PMID 37989590›Full record

ArticleeNeuro2023

A Novel Flp Reporter Mouse Shows That TRPA1 Expression Is Largely Limited to Sensory Neuron Subsets.

Mayur J Patil, Seol-Hee Kim, Parmvir K Bahia, Sanjay S Nair, Teresa S Darcey, Jailene Fiallo, Xiao Xia Zhu, Robert D Frisina, Stephen H Hadley, Thomas E Taylor-Clark

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Correlation of TRPA1 RNAscope and Agonist Responses.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024
    Article
  9. Review
  10. Article
  11. Nanoparticles-Mediated Modulation of TRP Channels: Advances and Therapeutic Potential.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mayur J PatilMolecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612.
Seol-Hee KimMolecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612.
Parmvir K BahiaMolecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612.ORCID 0000-0002-9553-5168
Sanjay S NairMolecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612.
Teresa S DarceyMolecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612.
Jailene FialloMolecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612.
Xiao Xia ZhuMedical Engineering, College of Engineering, University of South Florida, Tampa, Florida 33620.
Robert D FrisinaMedical Engineering, College of Engineering, University of South Florida, Tampa, Florida 33620.
Stephen H HadleyMolecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612.
Thomas E Taylor-ClarkMolecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612 ttaylorclark@usf.edu.ORCID 0000-0002-5056-2699
University of South Florida · US

Funding

Functional mapping of peripheral and central circuits for airway protection and breathingOT2OD023854 · OD · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C · 2016 to 2020
$10.8M
Comparative mapping of functionally distinct visceral afferent nociceptive pathwaysU01NS113868 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI KOLLARIK, MARIAN, TAYLOR-CLARK, THOMAS EDWARD · 2019 to 2021
$2.2M
Remodeled airway irritant reflexes as a cause of serious cardiovascular eventsR01HL152219 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI TAYLOR-CLARK, THOMAS EDWARD · 2021 to 2024
$2.1M
Identification and Activation Mechanisms of Vagal and Spinal Nociceptors in Esophageal MucosaR01DK110366 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI TAYLOR-CLARK, THOMAS EDWARD, YU, SHAOYONG · 2017 to 2020
$1.4M
Training in Research on Vascular Inflammation and InjuryT32HL160529 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Sarah Y Yuan · 2022 to 2026
$1.1M
Ionic and Structural Mechanisms for Sensory Neuromodulation of the EsophagusU01DK116311 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI TAYLOR-CLARK, THOMAS EDWARD · 2017 to 2019
$786k
NHLBI NIH HHS R01 HL152219NHLBI NIH HHS T32 HL160529NIDDK NIH HHS R01 DK110366NIDDK NIH HHS U01 DK116311NIH HHS OT2 OD023854NINDS NIH HHS U01 NS113868
6 · The paper itself

Abstract

Transient receptor potential ankyrin 1 (TRPA1) is a polymodal cation channel that is activated by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling. TRPA1 expression has been primarily identified in subsets of nociceptive sensory afferents and is considered a target for future analgesics. Nevertheless, TRPA1 has been implicated in other cell types including keratinocytes, epithelium, enterochromaffin cells, endothelium, astrocytes, and CNS neurons. Here, we developed a knock-in mouse that expresses the recombinase Flp

Indexed as

Transient Receptor Potential ChannelsAnimalsGanglia, SpinalGene ExpressionMiceSensory Receptor CellsSkinTRPA1 Cation ChannelTransient Receptor Potential ChannelsTRPA1 Cation ChannelTrpa1 protein, mouseafferentDRGmappingnociceptionTRPA1vagal

Identifiers

PMID37989590
PMCPMC10698635
OpenAlexW4388857645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.